TY - JOUR
T1 - DNA Methylation as a Molecular Mechanism of Carcinogenesis in World Trade Center Dust Exposure
T2 - Insights from a Structured Literature Review
AU - Tuminello, Stephanie
AU - Durmus, Nedim
AU - Snuderl, Matija
AU - Chen, Yu
AU - Shao, Yongzhao
AU - Reibman, Joan
AU - Arslan, Alan A.
AU - Taioli, Emanuela
N1 - Publisher Copyright:
© 2024 by the authors.
PY - 2024/10
Y1 - 2024/10
N2 - The collapse of the World Trade Center (WTC) buildings in New York City generated a large plume of dust and smoke. WTC dust contained human carcinogens including metals, asbestos, polycyclic aromatic hydrocarbons (PAHs), persistent organic pollutants (POPs, including polychlorinated biphenyls (PCBs) and dioxins), and benzene. Excess levels of many of these carcinogens have been detected in biological samples of WTC-exposed persons, for whom cancer risk is elevated. As confirmed in this structured literature review (n studies = 80), all carcinogens present in the settled WTC dust (metals, asbestos, benzene, PAHs, POPs) have previously been shown to be associated with DNA methylation dysregulation of key cancer-related genes and pathways. DNA methylation is, therefore, a likely molecular mechanism through which WTC exposures may influence the process of carcinogenesis.
AB - The collapse of the World Trade Center (WTC) buildings in New York City generated a large plume of dust and smoke. WTC dust contained human carcinogens including metals, asbestos, polycyclic aromatic hydrocarbons (PAHs), persistent organic pollutants (POPs, including polychlorinated biphenyls (PCBs) and dioxins), and benzene. Excess levels of many of these carcinogens have been detected in biological samples of WTC-exposed persons, for whom cancer risk is elevated. As confirmed in this structured literature review (n studies = 80), all carcinogens present in the settled WTC dust (metals, asbestos, benzene, PAHs, POPs) have previously been shown to be associated with DNA methylation dysregulation of key cancer-related genes and pathways. DNA methylation is, therefore, a likely molecular mechanism through which WTC exposures may influence the process of carcinogenesis.
KW - DNA methylation
KW - carcinogens
KW - epigenetics
KW - world trade center
UR - http://www.scopus.com/inward/record.url?scp=85207658208&partnerID=8YFLogxK
U2 - 10.3390/biom14101302
DO - 10.3390/biom14101302
M3 - Review article
C2 - 39456235
AN - SCOPUS:85207658208
SN - 2218-273X
VL - 14
JO - Biomolecules
JF - Biomolecules
IS - 10
M1 - 1302
ER -