DNA duplex formation with a coarse-grained model

Maciej Maciejczyk, Aleksandar Spasic, Adam Liwo, Harold A. Scheraga

Research output: Contribution to journalArticlepeer-review

26 Scopus citations


A middle-resolution coarse-grained model of DNA is proposed. The DNA chain is built of spherical and planar rigid bodies connected by elastic virtual bonds. The bonded part of the potential energy function is fit to potentials of mean force of model systems. The rigid bodies are sets of neutral, charged, and dipolar beads. Electrostatic and van der Waals interactions are parametrized by our recently developed procedure [Maciejczyk, M.; Spasic, A.; Liwo, A.; Scheraga, H.A. J. Comp. Chem. 2010, 31, 1644]. Interactions with the solvent and an ionic cloud are approximated by a multipole-multipole Debye-Hückel model. A very efficient R-RATTLE algorithm, for integrating the movement of rigid bodies, is implemented. It is the first coarse-grained model, in which both bonded and nonbonded interactions were parametrized ab initio and which folds stable double helices from separated complementary strands, with the final conformation close to the geometry of experimentally determined structures.

Original languageEnglish
Pages (from-to)5020-5035
Number of pages16
JournalJournal of Chemical Theory and Computation
Issue number11
StatePublished - 11 Nov 2014
Externally publishedYes


Dive into the research topics of 'DNA duplex formation with a coarse-grained model'. Together they form a unique fingerprint.

Cite this