DM-nitrophen AM is caged magnesium

Graham C.R. Ellis-Davies

doi:10.1016/j.ceca.2006.02.002

DM-nitrophen AM is caged magnesium

Graham C.R. Ellis-Davies

Research output: Contribution to journal › Comment/debate

24 Scopus citations

Abstract

DM-nitrophen is a photolabile derivative of EDTA and therefore functions as either caged Ca²⁺ or caged Mg²⁺. Several papers have been published recently which use the AM ester to load intact cells with DM-nitrophen; under these conditions it is caged Mg²⁺. In this commentary, I give a short history of the development and application of caged Ca²⁺ probes, explaining why EGTA and BAPTA-based Ca²⁺ cages are to be preferred for the photorelease of Ca²⁺ under normal intracellular conditions.

Original language	English
Pages (from-to)	471-473
Number of pages	3
Journal	Cell Calcium
Volume	39
Issue number	6
DOIs	https://doi.org/10.1016/j.ceca.2006.02.002
State	Published - Jun 2006
Externally published	Yes

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10.1016/j.ceca.2006.02.002

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title = "DM-nitrophen AM is caged magnesium",

abstract = "DM-nitrophen is a photolabile derivative of EDTA and therefore functions as either caged Ca2+ or caged Mg2+. Several papers have been published recently which use the AM ester to load intact cells with DM-nitrophen; under these conditions it is caged Mg2+. In this commentary, I give a short history of the development and application of caged Ca2+ probes, explaining why EGTA and BAPTA-based Ca2+ cages are to be preferred for the photorelease of Ca2+ under normal intracellular conditions.",

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N2 - DM-nitrophen is a photolabile derivative of EDTA and therefore functions as either caged Ca2+ or caged Mg2+. Several papers have been published recently which use the AM ester to load intact cells with DM-nitrophen; under these conditions it is caged Mg2+. In this commentary, I give a short history of the development and application of caged Ca2+ probes, explaining why EGTA and BAPTA-based Ca2+ cages are to be preferred for the photorelease of Ca2+ under normal intracellular conditions.

AB - DM-nitrophen is a photolabile derivative of EDTA and therefore functions as either caged Ca2+ or caged Mg2+. Several papers have been published recently which use the AM ester to load intact cells with DM-nitrophen; under these conditions it is caged Mg2+. In this commentary, I give a short history of the development and application of caged Ca2+ probes, explaining why EGTA and BAPTA-based Ca2+ cages are to be preferred for the photorelease of Ca2+ under normal intracellular conditions.

UR - https://www.scopus.com/pages/publications/33646380064

U2 - 10.1016/j.ceca.2006.02.002

DO - 10.1016/j.ceca.2006.02.002

M3 - Comment/debate

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AN - SCOPUS:33646380064

SN - 0143-4160

VL - 39

SP - 471

EP - 473

JO - Cell Calcium

JF - Cell Calcium

IS - 6

ER -

DM-nitrophen AM is caged magnesium

Abstract

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