Dizocilpine-induced accuracy deficits in a visual signal detection task are not present following d-cycloserine administration in rats

W. Matthew Howe, Joshua A. Burk

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

The N-methyl-d-aspartate (NMDA) receptor system is thought to be underactive in schizophrenia which may contribute to attentional dysfunction in this disease. In a visual signal detection task that required discrimination of signaled-trials from trials with no signal, the NMDA receptor antagonist, dizocilpine (0.05 mg/kg), increased errors on non-signal trials. Co-administration of dizocilpine and 10.0 mg/kg d-cycloserine, a co-agonist at the glycine site on the NMDA receptor, significantly decreased the error rate on non-signal trials compared to dizocilpine alone. These results suggest that drugs targeting the glycine site may be beneficial for attenuating attentional deficits associated with an underactive NMDA receptor system.

Original languageEnglish
Pages (from-to)87-90
Number of pages4
JournalEuropean Journal of Pharmacology
Volume577
Issue number1-3
DOIs
StatePublished - 22 Dec 2007
Externally publishedYes

Keywords

  • Glutamate
  • MK-801
  • Schizophrenia
  • Vigilance

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