TY - JOUR
T1 - Diverging white matter trajectories in children after traumatic brain injury
AU - Dennis, Emily L.
AU - Rashid, Faisal
AU - Ellis, Monica U.
AU - Babikian, Talin
AU - Vlasova, Roza M.
AU - Villalon-Reina, Julio E.
AU - Jin, Yan
AU - Olsen, Alexander
AU - Mink, Richard
AU - Babbitt, Christopher
AU - Johnson, Jeffrey
AU - Giza, Christopher C.
AU - Thompson, Paul M.
AU - Asarnow, Robert F.
N1 - Publisher Copyright:
© 2017 American Academy of Neurology.
PY - 2017/4/11
Y1 - 2017/4/11
N2 - Objective: To examine longitudinal trajectories of white matter organization in pediatric moderate/severe traumatic brain injury (msTBI) over a 12-month period. Methods: We studied 21 children (16 M/5 F) with msTBI, assessed 2-5 months postinjury and again 13-19 months postinjury, as well as 20 well-matched healthy control children. We assessed corpus callosum function through interhemispheric transfer time (IHTT), measured using event-related potentials, and related this to diffusion-weighted MRI measures of white matter (WM) microstructure. At the first time point, half of the patients with TBI had significantly slower IHTT (TBI-slow-IHTT, n = 11) and half were in the normal range (TBI-normal-IHTT, n = 10). Results: The TBI-normal-IHTT group did not differ significantly from healthy controls, either in WM organization in the chronic phase or in the longitudinal trajectory of WM organization between the 2 evaluations. In contrast, the WM organization of the TBI-slow-IHTT group was significantly lower than in healthy controls across a large portion of the WM. Longitudinal analyses showed that the TBI-slow-IHTT group experienced a progressive decline between the 2 evaluations in WM organization throughout the brain. Conclusions: We present preliminary evidence suggesting a potential biomarker that identifies a subset of patients with impaired callosal organization in the first months postinjury who subsequently experience widespread continuing and progressive degeneration in the first year postinjury.
AB - Objective: To examine longitudinal trajectories of white matter organization in pediatric moderate/severe traumatic brain injury (msTBI) over a 12-month period. Methods: We studied 21 children (16 M/5 F) with msTBI, assessed 2-5 months postinjury and again 13-19 months postinjury, as well as 20 well-matched healthy control children. We assessed corpus callosum function through interhemispheric transfer time (IHTT), measured using event-related potentials, and related this to diffusion-weighted MRI measures of white matter (WM) microstructure. At the first time point, half of the patients with TBI had significantly slower IHTT (TBI-slow-IHTT, n = 11) and half were in the normal range (TBI-normal-IHTT, n = 10). Results: The TBI-normal-IHTT group did not differ significantly from healthy controls, either in WM organization in the chronic phase or in the longitudinal trajectory of WM organization between the 2 evaluations. In contrast, the WM organization of the TBI-slow-IHTT group was significantly lower than in healthy controls across a large portion of the WM. Longitudinal analyses showed that the TBI-slow-IHTT group experienced a progressive decline between the 2 evaluations in WM organization throughout the brain. Conclusions: We present preliminary evidence suggesting a potential biomarker that identifies a subset of patients with impaired callosal organization in the first months postinjury who subsequently experience widespread continuing and progressive degeneration in the first year postinjury.
UR - http://www.scopus.com/inward/record.url?scp=85018632946&partnerID=8YFLogxK
U2 - 10.1212/WNL.0000000000003808
DO - 10.1212/WNL.0000000000003808
M3 - Article
C2 - 28298549
AN - SCOPUS:85018632946
SN - 0028-3878
VL - 88
SP - 1392
EP - 1399
JO - Neurology
JF - Neurology
IS - 15
ER -