TY - JOUR
T1 - Diurnal Cortisol Concentrations and Growth Indexes of 12- to 48-Month-Old Children from Mexico City
AU - Rosa-Parra, Jose A.
AU - Tamayo-Ortiz, Marcela
AU - Lamadrid-Figueroa, Hector
AU - Cantoral-Preciado, Alejandra
AU - Montoya, Alejandra
AU - Wright, Rosalind J.
AU - Baccarelli, Andrea A.
AU - Just, Allan C.
AU - Svensson, Katherine
AU - Wright, Robert O.
AU - Téllez-Rojo, Martha M.
N1 - Publisher Copyright:
© 2018 Endocrine Society.
PY - 2018/9/1
Y1 - 2018/9/1
N2 - Context: Early life cortisol plays an important role in bone, muscle, and fat mobilization processes, which could influence body composition, affecting anthropometric indicators such as weight and height. Objective: To explore the association between diurnal cortisol levels and growth indexes in children from 12 to 48 months of age. Design: This study includes data from 404 children from the Programming Research in Obesity, Growth, Environment and Social Stressors Mexican birth cohort. Cortisol was measured in eight saliva samples collected at four time points during the day (from wakeup to bedtime), over 2 days, when the child was either 12, 18, or 24 months old. Total daytime cortisol levels were calculated by averaging the area under the curve (AUC) for the 2 days. Height and weight were measured from 12 to 48 months of age. Growth indexes were constructed according to z scores following World Health Organization standards: weight-for-age z score (Z-WFA), height/length-for-age z score, weight-for-height/length z score (Z-WFH), and body mass indexfor-age z score (Z-BMIFA). Mixed models were used to analyze the association between cortisol AUC quartiles and growth indexes. Results: Cortisol showed an inverted U-shaped association with the four growth indexes. Compared with the first quartile, all quartiles had a positive association with indexes that include weight, with the second quartile having the strongest association, resulting in an average change of b (95% CI) 0.38 (0.130.64) for Z-WFA, 0.36 (0.100.62) for Z-WFH, and 0.43 (0.170.69) for Z-BMIFA. Conclusions: Results suggest that early life daytime cortisol levels, as a reflection of hypothalamicpituitary-adrenal axis development, might influence growth in early infancy.
AB - Context: Early life cortisol plays an important role in bone, muscle, and fat mobilization processes, which could influence body composition, affecting anthropometric indicators such as weight and height. Objective: To explore the association between diurnal cortisol levels and growth indexes in children from 12 to 48 months of age. Design: This study includes data from 404 children from the Programming Research in Obesity, Growth, Environment and Social Stressors Mexican birth cohort. Cortisol was measured in eight saliva samples collected at four time points during the day (from wakeup to bedtime), over 2 days, when the child was either 12, 18, or 24 months old. Total daytime cortisol levels were calculated by averaging the area under the curve (AUC) for the 2 days. Height and weight were measured from 12 to 48 months of age. Growth indexes were constructed according to z scores following World Health Organization standards: weight-for-age z score (Z-WFA), height/length-for-age z score, weight-for-height/length z score (Z-WFH), and body mass indexfor-age z score (Z-BMIFA). Mixed models were used to analyze the association between cortisol AUC quartiles and growth indexes. Results: Cortisol showed an inverted U-shaped association with the four growth indexes. Compared with the first quartile, all quartiles had a positive association with indexes that include weight, with the second quartile having the strongest association, resulting in an average change of b (95% CI) 0.38 (0.130.64) for Z-WFA, 0.36 (0.100.62) for Z-WFH, and 0.43 (0.170.69) for Z-BMIFA. Conclusions: Results suggest that early life daytime cortisol levels, as a reflection of hypothalamicpituitary-adrenal axis development, might influence growth in early infancy.
UR - http://www.scopus.com/inward/record.url?scp=85054126807&partnerID=8YFLogxK
U2 - 10.1210/jc.2018-00550
DO - 10.1210/jc.2018-00550
M3 - Article
C2 - 30020462
AN - SCOPUS:85054126807
SN - 0021-972X
VL - 103
SP - 3386
EP - 3393
JO - Journal of Clinical Endocrinology and Metabolism
JF - Journal of Clinical Endocrinology and Metabolism
IS - 9
ER -