@article{d57cc1ecb4b244d8b3d12db6b28b133a,
title = "Distribution of neurofibrillary tangles and senile plaques in the cerebral cortex in postencephalitic parkinsonism",
abstract = "Postencephalitic parkinsonism is characterized neuropathologically by severe loss of pigmented neurons in the substantia nigra and the presence of high densities of neurofibrillary tangles in several brainstem structures. In 5 cases of postencephalitic parkinsonism, we observed that the neurofibrillary tangle distribution in the cerebral cortex predominated in the hippocampus and entorhinal cortex. In the prefrontal and inferior temporal cortex, neurofibrillary tangles were preferentially localized in layers II and III. This pattern contrasts with the neurofibrillary tangle distribution observed in neocortical areas of Alzheimer's disease cases, where neurofibrillary tangles are denser in layer V than in layer III. These results suggest that specific elements of the cortical circuitry might be differentially affected in postencephalitic parkinsonism as compared to Alzheimer's disease, and that cortical involvement is likely to be a common feature of this condition.",
keywords = "Alzheimer's disease, Corticocortical connection, Human neocortex, Neurofibrillary tangle, Postencephalitic parkinsonism, Tau protein",
author = "Hof, {Patrick R.} and Alain Charpiot and Andr{\'e} Delacourte and Luc Bu{\'e}e and Dushyant Purohit and Perl, {Daniel P.} and Constantin Bouras",
note = "Funding Information: We thank M. Surini, N. Archin, W. Janssen, and R. Woolley for expert technical assistance, Dr. W.G. Young for software development, and Dr. J.H. Morrison for helpful discussions. This work was supported by the Brookdale Foundation and the American Health Assistance Foundation (to RR.H.), NIH AG05138 and AG08802 (to D.RR), and ADERMA and INSERM clinical network CAR 489016 (to A.D.), I Arnold, S.I'., ltvman, B.T.. Flory, J.. Damasio, A.R, and Van Hoesen, G.W.. The topographical und neuroanatomical distribu-lion of neurotibrillary tangles and neuritic plaques in the cerebral cortex of patients with Alzheimer's disease. Cerebral Cortex, 1 (1991) 1()3 ll6. 2 Bouras, C.. Hof, P.R., Guntern, R. and Morrison, J.H., Down's syndrome {I)S I, dementia pugilistica (DPI, and Alzheimer's disease (AD): a quantitative neuropathologic comparison, Proc. Soc. Ncu-rosci., 16 (1990) 1264. 3 ('alne. D.B. and Less. A.J., Late progression of post-encephalitic",
year = "1992",
month = may,
day = "11",
doi = "10.1016/0304-3940(92)90846-Y",
language = "English",
volume = "139",
pages = "10--14",
journal = "Neuroscience Letters",
issn = "0304-3940",
publisher = "Elsevier Ireland Ltd",
number = "1",
}