Distribution and risk of the second discordant primary cancers combined after a specific first primary cancer in German and Swedish cancer registries

GEKID Cancer Survival Working Group

Research output: Contribution to journalArticlepeer-review

26 Scopus citations

Abstract

We aimed at investigating the distribution and risk of all second discordant primary cancers (SDPCs) after a specific first primary cancer in Germany and Sweden to provide etiological understanding of SDPCs and insight into their incidence rates and recording practices. Among 1,537,004 survivors of first primary cancers in Germany and 588,103 in Sweden, overall 80,162 and 32,544 SDPCs were recorded, respectively. Standardized incidence ratios (SIRs) of all SDPCs were elevated at levels between 1.1 and 2.1 after 23 (out of overall 29) cancers in Germany and at levels between 1.1 and 1.6 after 24 cancers in Sweden, and among them, elevated SIRs were found after 19 cancers in both populations. Decreased SIRs at levels ranging from 0.5 to 0.9 were found for some cancers with poor prognosis in Germany only. We found elevated risk after 19 out of 29 cancers in both countries, suggesting common etiology of SDPCs after most of first cancers and registration similarity. Decreased risks after some fatal cancers were found only in Germany, which may be attributed to reporting practices or missed death data in Germany.

Original languageEnglish
Pages (from-to)152-166
Number of pages15
JournalCancer Letters
Volume369
Issue number1
DOIs
StatePublished - 1 Dec 2015
Externally publishedYes

Keywords

  • Age at diagnosis
  • Cancer registry
  • Discordant cancer
  • Second primary cancers
  • Standardized incidence ratios

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