Distinctive roles for amygdalar CREB in reconsolidation and extinction of fear memory

Natalie C. Tronson; Shari L. Wiseman; Rachael L. Neve; Eric J. Nestler; Peter Olausson; Jane R. Taylor

doi:10.1101/lm.025783.112

Distinctive roles for amygdalar CREB in reconsolidation and extinction of fear memory

Natalie C. Tronson
, Shari L. Wiseman
, Rachael L. Neve
, Eric J. Nestler
, Peter Olausson
, Jane R. Taylor

Research output: Contribution to journal › Article › peer-review

29 Scopus citations

Abstract

Cyclic AMP response element binding protein (CREB) plays a critical role in fear memory formation. Here we determined the role of CREB selectively within the amygdala in reconsolidation and extinction of auditory fear. Viral overexpression of the inducible cAMP early repressor (ICER) or the dominant-negative mCREB, specifically within the lateral amygdala disrupted reconsolidation of auditory fear memories. In contrast, manipulations of CREB in the amygdala did not modify extinction of fear. These findings suggest that the role of CREB in modulation of memory after retrieval is dynamic and that CREB activity in the basolateral amygdala is involved in fear memory reconsolidation.

Original language	English
Pages (from-to)	178-181
Number of pages	4
Journal	Learning and Memory
Volume	19
Issue number	5
DOIs	https://doi.org/10.1101/lm.025783.112
State	Published - May 2012

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title = "Distinctive roles for amygdalar CREB in reconsolidation and extinction of fear memory",

abstract = "Cyclic AMP response element binding protein (CREB) plays a critical role in fear memory formation. Here we determined the role of CREB selectively within the amygdala in reconsolidation and extinction of auditory fear. Viral overexpression of the inducible cAMP early repressor (ICER) or the dominant-negative mCREB, specifically within the lateral amygdala disrupted reconsolidation of auditory fear memories. In contrast, manipulations of CREB in the amygdala did not modify extinction of fear. These findings suggest that the role of CREB in modulation of memory after retrieval is dynamic and that CREB activity in the basolateral amygdala is involved in fear memory reconsolidation.",

author = "Tronson, \{Natalie C.\} and Wiseman, \{Shari L.\} and Neve, \{Rachael L.\} and Nestler, \{Eric J.\} and Peter Olausson and Taylor, \{Jane R.\}",

year = "2012",

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AU - Tronson, Natalie C.

AU - Wiseman, Shari L.

AU - Neve, Rachael L.

AU - Nestler, Eric J.

AU - Olausson, Peter

AU - Taylor, Jane R.

PY - 2012/5

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N2 - Cyclic AMP response element binding protein (CREB) plays a critical role in fear memory formation. Here we determined the role of CREB selectively within the amygdala in reconsolidation and extinction of auditory fear. Viral overexpression of the inducible cAMP early repressor (ICER) or the dominant-negative mCREB, specifically within the lateral amygdala disrupted reconsolidation of auditory fear memories. In contrast, manipulations of CREB in the amygdala did not modify extinction of fear. These findings suggest that the role of CREB in modulation of memory after retrieval is dynamic and that CREB activity in the basolateral amygdala is involved in fear memory reconsolidation.

AB - Cyclic AMP response element binding protein (CREB) plays a critical role in fear memory formation. Here we determined the role of CREB selectively within the amygdala in reconsolidation and extinction of auditory fear. Viral overexpression of the inducible cAMP early repressor (ICER) or the dominant-negative mCREB, specifically within the lateral amygdala disrupted reconsolidation of auditory fear memories. In contrast, manipulations of CREB in the amygdala did not modify extinction of fear. These findings suggest that the role of CREB in modulation of memory after retrieval is dynamic and that CREB activity in the basolateral amygdala is involved in fear memory reconsolidation.

UR - https://www.scopus.com/pages/publications/84861140739

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SN - 1072-0502

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SP - 178

EP - 181

JO - Learning and Memory

JF - Learning and Memory

IS - 5

ER -

Distinctive roles for amygdalar CREB in reconsolidation and extinction of fear memory

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