@article{a30e7ec672a74cc6a6dfaf1be6da3c90,
title = "Distinct regional atrophy in the corpus callosum of patients with temporal lobe epilepsy",
abstract = "We analysed the influence of mesial temporal lobe epilepsy on the thickness of the corpus callosum (CC) in a large sample of well-characterized patients (n = 96) and healthy controls (n = 28). In particular, we investigated whether callosal structures are differentially affected depending on the affected hemisphere and age of epilepsy onset. Overall, we observed that epilepsy is associated with a decreased thickness in posterior callosal regions. Patients with an early onset, especially patients with left onset, additionally exhibited a smaller callosal thickness in more anterior and midbody regions. These findings may reflect non-specific as well as specific effects of temporal lobe epilepsy on CC development and interhemispheric connectivity.",
keywords = "Corpus callosum, MRI, Temporal lobe epilepsy",
author = "Bernd Weber and Eileen Luders and Jennifer Faber and Sabine Richter and Quesada, \{Carlos M.\} and Horst Urbach and Thompson, \{Paul M.\} and Toga, \{Arthur W.\} and Elger, \{Christian E.\} and Christoph Helmstaedter",
note = "Funding Information: Carlos M. Quesada and Bernd Weber were supported by the BMBF Grant 01GW0511. Paul M. Thompson was supported by the National Institute for Biomedical Imaging and Bioengineering, the National Center for Research Resources, the National Institute for Neurological Disorders and Stroke, National Institute on Aging and the National Institute for Child Health and Development (EB01651, RR019771, AG016570, NS049194 and HD050735). Moreover, this work was supported by the National Institutes of Health through the NIH Roadmap for Medical Research, grant U54 RR021813 entitled Center for Computational Biology (CCB). Information on the National Centers for Biomedical Computing can be obtained from <http://nihroadmap. nih.gov/bioinformatics>. Additional support was provided by the NIH/NCRR resource grant P41 RR013642.",
year = "2007",
month = dec,
doi = "10.1093/brain/awm186",
language = "English",
volume = "130",
pages = "3149--3154",
journal = "Brain",
issn = "0006-8950",
publisher = "Oxford University Press",
number = "12",
}