Distinct neuronal vulnerability and metabolic dysfunctions are characteristic features of fast-progressing Alzheimer's patients with Lewy bodies

Keyphrases

• Metabolic Dysfunction 100%
• Alzheimer's Disease 100%
• Lewy Bodies 100%
• Neuronal Vulnerability 100%
• Alzheimer Patients 100%
• Alpha-synuclein (α-syn) 60%
• Dementia with Lewy Bodies 60%
• Tau Protein 60%
• Comorbidity 40%
• Alzheimer's Dementia 40%
• Progression Rate 40%
• Dementia Progression 40%
• Co-pathology 40%
• Dementia 20%
• Clinical Trials 20%
• Alzheimer's Disease Patient 20%
• Biochemical Methods 20%
• Postmortem Tissue 20%
• Prefrontal Cortex 20%
• Regional Vulnerability 20%
• Between-person 20%
• Immunoassay 20%
• Temporal Cortex 20%
• Proteomic Profiling 20%
• Metabolic Pathway 20%
• Cohort Data 20%
• Neuronal Population 20%
• Patient Clustering 20%
• Protein Accumulation 20%
• Longitudinal Cohort 20%
• Selective Neuronal Vulnerability 20%
• Molecular Components 20%
• Tau Aggregation 20%
• TDP-43 Pathology 20%
• Lewy Pathology 20%
• Insoluble tau 20%
• Oligomeric tau 20%
• Cross-seeding 20%

Biochemistry, Genetics and Molecular Biology

• Tau Protein 100%
• Synuclein 100%
• Tau 66%
• Comorbidity 66%
• Clinical Trial 33%
• Immunoassay 33%
• Transactive Response Dna Binding Protein-43 33%
• Proteomics 33%

Neuroscience

• Alzheimer's Disease 100%
• Lewy Body 100%
• Synuclein 37%
• Dementia with Lewy Bodies 37%
• Tau Protein 37%
• Comorbidity 25%
• Temporal Lobe 12%
• Prefrontal Cortex 12%
• Immunoassay 12%
• Proteomics 12%