Distinct Histone H3 Lysine 27 Modifications Dictate Different Outcomes of Gene Transcription

Tsuyoshi Konuma, Ming Ming Zhou

Research output: Contribution to journalReview articlepeer-review

1 Scopus citations

Abstract

Site-specific histone modifications have long been recognized to play an important role in directing gene transcription in chromatin in biology of health and disease. However, concrete illustration of how different histone modifications in a site-specific manner dictate gene transcription outcomes, as postulated in the influential “Histone code hypothesis”, introduced by Allis and colleagues in 2000, has been lacking. In this review, we summarize our latest understanding of the dynamic regulation of gene transcriptional activation, silence, and repression in chromatin that is directed distinctively by histone H3 lysine 27 acetylation, methylation, and crotonylation, respectively. This represents a special example of a long-anticipated verification of the “Histone code hypothesis.”

Original languageEnglish
Article number168376
JournalJournal of Molecular Biology
Volume436
Issue number7
DOIs
StatePublished - 1 Apr 2024

Keywords

  • chromatin biology
  • gene transcription
  • histone modifications

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