Dissolution of stones by oral and irrigative therapy

Ruslan Korets; Joseph A. Graversen; Mantu Gupta

doi:10.1007/978-1-4471-4387-1_66

Dissolution of stones by oral and irrigative therapy

Ruslan Korets, Joseph A. Graversen, Mantu Gupta

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

2 Scopus citations

Abstract

Advancement in percutaneous and endoscopic techniques has revolutionized surgical treatment options for upper and lower urinary tract calculi. However, while the use of oral and irrigative therapies for stone dissolution has declined over the last decades, these therapies continue to serve as a safe alternative to surgery, especially in patients with significant comorbidities. This chapter examines principles of chemolysis for component-specific stone dissolution including pH manipulation, cation chelation, and mixed disulfide bond formation, as well as setup and deployment of percutaneous irrigation systems.

Original language	English
Title of host publication	Urolithiasis
Subtitle of host publication	Basic Science and Clinical Practice
Publisher	Springer-Verlag London Ltd
Pages	533-537
Number of pages	5
ISBN (Electronic)	9781447143871
ISBN (Print)	9781447143833
DOIs	https://doi.org/10.1007/978-1-4471-4387-1_66
State	Published - 1 Jan 2012
Externally published	Yes

Keywords

Acetohydroxamic acid
Alpha-mercaptopropionylglycine
Chemolysis
Cystine
Hemiacidrin
Irrigation system
Potassium citrate
Stone dissolution
Struvite
THAM
Uric acid
Urinary alkalinization

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abstract = "Advancement in percutaneous and endoscopic techniques has revolutionized surgical treatment options for upper and lower urinary tract calculi. However, while the use of oral and irrigative therapies for stone dissolution has declined over the last decades, these therapies continue to serve as a safe alternative to surgery, especially in patients with significant comorbidities. This chapter examines principles of chemolysis for component-specific stone dissolution including pH manipulation, cation chelation, and mixed disulfide bond formation, as well as setup and deployment of percutaneous irrigation systems.",

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AU - Gupta, Mantu

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KW - Alpha-mercaptopropionylglycine

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KW - Cystine

KW - Hemiacidrin

KW - Irrigation system

KW - Potassium citrate

KW - Stone dissolution

KW - Struvite

KW - THAM

KW - Uric acid

KW - Urinary alkalinization

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BT - Urolithiasis

PB - Springer-Verlag London Ltd

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Dissolution of stones by oral and irrigative therapy

Abstract

Keywords

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