Dissociation of prolactin response to thyrotropin-releasing hormone and metoclopramide in chronic renal failure

Derek Leroith, Gabriel Danovitz, Stefan Trestan, Irving M. Spitz

Research output: Contribution to journalArticlepeer-review

14 Scopus citations

Abstract

PRL secretion was evaluated in 14 males with chronic renal failure on long term hemodialysis. Twelve had basal hyperprolactinemia. Ten subjects were challenged with TRH in doses ranging from 200-1000 μg. None of them responded to 200 or 500 μg TRH, although 2 of 4 subjects tested did respond to 1000 μg TRH. In contrast, all 4 subjects challenged with metoclopramide did have PRL responses which were indistinguishable from those of the controls. These results indicate that there is a dissociation in responsiveness to metoclopramide and TRH in chronic renal failure.

Original languageEnglish
Pages (from-to)815-817
Number of pages3
JournalJournal of Clinical Endocrinology and Metabolism
Volume49
Issue number6
DOIs
StatePublished - Dec 1979
Externally publishedYes

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