Dissociation of cold-water swin and morphine analgesia in Brattleboro rats with diabetes insipidus

Richard J. Bodnar; Earl A. Zimmerman; Gajanan Nilaver; Alfred Mansour; Lucy W. Thomas; Dennis D. Kelly; Murray Glusman

doi:10.1016/0024-3205(80)90361-6

Dissociation of cold-water swin and morphine analgesia in Brattleboro rats with diabetes insipidus

Richard J. Bodnar, Earl A. Zimmerman, Gajanan Nilaver, Alfred Mansour, Lucy W. Thomas, Dennis D. Kelly, Murray Glusman

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Abstract

The present study examined whether vasopressin mediated the analgesic response to morphine and cold-water stress by comparing the analgesic responses of homozygous Brattleboro rats with diabetes insipidus with those of normal rats of the same strain of similar weight. Brattleboro rats exhibited hypersensitive responses to foot shock which were brought back to within normal limits by systemic administration of arginine vasopressin and desamino-D-arginine vasopressin. While Brattleboro rats failed to display an analgesic response to cold-water swim stress, they displayed a normal analgesic response to morphine. These results provide further evidence for dissociation of pain-inhibitory mechanisms into opioid and non-opioid components, and suggests that vasopressin might be involved in the elucidation of the latter component.

Original language	English
Pages (from-to)	1581-1590
Number of pages	10
Journal	Life Sciences
Volume	26
Issue number	19
DOIs	https://doi.org/10.1016/0024-3205(80)90361-6
State	Published - 12 May 1980
Externally published	Yes

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title = "Dissociation of cold-water swin and morphine analgesia in Brattleboro rats with diabetes insipidus",

abstract = "The present study examined whether vasopressin mediated the analgesic response to morphine and cold-water stress by comparing the analgesic responses of homozygous Brattleboro rats with diabetes insipidus with those of normal rats of the same strain of similar weight. Brattleboro rats exhibited hypersensitive responses to foot shock which were brought back to within normal limits by systemic administration of arginine vasopressin and desamino-D-arginine vasopressin. While Brattleboro rats failed to display an analgesic response to cold-water swim stress, they displayed a normal analgesic response to morphine. These results provide further evidence for dissociation of pain-inhibitory mechanisms into opioid and non-opioid components, and suggests that vasopressin might be involved in the elucidation of the latter component.",

author = "Bodnar, {Richard J.} and Zimmerman, {Earl A.} and Gajanan Nilaver and Alfred Mansour and Thomas, {Lucy W.} and Kelly, {Dennis D.} and Murray Glusman",

note = "Funding Information: This work was supported by USPHS Z0337 (E.A.Z.) and N.Y.S.H.R.C.",

year = "1980",

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doi = "10.1016/0024-3205(80)90361-6",

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T1 - Dissociation of cold-water swin and morphine analgesia in Brattleboro rats with diabetes insipidus

AU - Bodnar, Richard J.

AU - Zimmerman, Earl A.

AU - Nilaver, Gajanan

AU - Mansour, Alfred

AU - Thomas, Lucy W.

AU - Kelly, Dennis D.

AU - Glusman, Murray

N1 - Funding Information: This work was supported by USPHS Z0337 (E.A.Z.) and N.Y.S.H.R.C.

PY - 1980/5/12

Y1 - 1980/5/12

N2 - The present study examined whether vasopressin mediated the analgesic response to morphine and cold-water stress by comparing the analgesic responses of homozygous Brattleboro rats with diabetes insipidus with those of normal rats of the same strain of similar weight. Brattleboro rats exhibited hypersensitive responses to foot shock which were brought back to within normal limits by systemic administration of arginine vasopressin and desamino-D-arginine vasopressin. While Brattleboro rats failed to display an analgesic response to cold-water swim stress, they displayed a normal analgesic response to morphine. These results provide further evidence for dissociation of pain-inhibitory mechanisms into opioid and non-opioid components, and suggests that vasopressin might be involved in the elucidation of the latter component.

AB - The present study examined whether vasopressin mediated the analgesic response to morphine and cold-water stress by comparing the analgesic responses of homozygous Brattleboro rats with diabetes insipidus with those of normal rats of the same strain of similar weight. Brattleboro rats exhibited hypersensitive responses to foot shock which were brought back to within normal limits by systemic administration of arginine vasopressin and desamino-D-arginine vasopressin. While Brattleboro rats failed to display an analgesic response to cold-water swim stress, they displayed a normal analgesic response to morphine. These results provide further evidence for dissociation of pain-inhibitory mechanisms into opioid and non-opioid components, and suggests that vasopressin might be involved in the elucidation of the latter component.

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JO - Life Sciences

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ER -

Dissociation of cold-water swin and morphine analgesia in Brattleboro rats with diabetes insipidus

Abstract

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