TY - JOUR
T1 - Dissociable cognitive patterns related to depression and anxiety in multiple sclerosis
AU - Leavitt, Victoria M.
AU - Brandstadter, Rachel
AU - Fabian, Michelle
AU - Katz Sand, Ilana
AU - Klineova, Sylvia
AU - Krieger, Stephen
AU - Lewis, Christina
AU - Lublin, Fred
AU - Miller, Aaron
AU - Pelle, Gabrielle
AU - Buyukturkoglu, Korhan
AU - De Jager, Phillip L.
AU - Li, Peipei
AU - Riley, Claire S.
AU - Tsapanou, Angeliki
AU - Sumowski, James F.
N1 - Funding Information:
The authors wish to thank members of the MEM CONNECT study team from the Department of Neurology at Columbia University Irving Medical Center; and the RADIEMS study team from the Corinne Goldsmith Dickinson Center for Multiple Sclerosis at Icahn School of Medicine at Mount Sinai and the Cognitive Neuroscience Division within the Department of Neurology at Columbia University Irving Medical Center. The authors thank the MS patients from both centers whose participation made this research possible. The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This study was funded by the National Multiple Sclerosis Society (RG4810A1/1) to V.M.L. and the National Institutes of Health (National Center for Medical Rehabilitation Research of the National Institute of Child Health and Development, R01 HD082176) to J.F.S.
Publisher Copyright:
© The Author(s), 2019.
PY - 2020/9/1
Y1 - 2020/9/1
N2 - Background: Individuals with multiple sclerosis (MS) frequently present with depression and anxiety, as well as cognitive impairment, challenging clinicians to disentangle interrelationships among these symptoms. Objective: To identify cognitive functions associated with anxiety and depression in MS. Methods: Mood and cognition were measured in 185 recently diagnosed patients (Reserve Against Disability in Early Multiple Sclerosis (RADIEMS) cohort), and an independent validation sample (MEM CONNECT cohort, n = 70). Partial correlations evaluated relationships of cognition to anxiety and depression controlling for age, sex, education, and premorbid verbal intelligence. Results: In RADIEMS cohort, lower anxiety was associated with better nonverbal memory (rp = –0.220, p = 0.003) and lower depression to better attention/processing speed (rp = –0.241, p = 0.001). Consistently, in MEM CONNECT cohort, lower anxiety was associated with better nonverbal memory (rp = –0.271, p = 0.028) and lower depression to better attention/processing speed (rp = –0.367, p = 0.002). Relationships were unchanged after controlling for T2 lesion volume and fatigue. Conclusion: Consistent mood–cognition relationships were identified in two independent cohorts of MS patients, suggesting that cognitive correlates of anxiety and depression are separable. This dissociation may support more precise models to inform treatment development. Treatment of mood symptoms may mitigate effects on cognition and/or treatment of cognition may mitigate effects on mood.
AB - Background: Individuals with multiple sclerosis (MS) frequently present with depression and anxiety, as well as cognitive impairment, challenging clinicians to disentangle interrelationships among these symptoms. Objective: To identify cognitive functions associated with anxiety and depression in MS. Methods: Mood and cognition were measured in 185 recently diagnosed patients (Reserve Against Disability in Early Multiple Sclerosis (RADIEMS) cohort), and an independent validation sample (MEM CONNECT cohort, n = 70). Partial correlations evaluated relationships of cognition to anxiety and depression controlling for age, sex, education, and premorbid verbal intelligence. Results: In RADIEMS cohort, lower anxiety was associated with better nonverbal memory (rp = –0.220, p = 0.003) and lower depression to better attention/processing speed (rp = –0.241, p = 0.001). Consistently, in MEM CONNECT cohort, lower anxiety was associated with better nonverbal memory (rp = –0.271, p = 0.028) and lower depression to better attention/processing speed (rp = –0.367, p = 0.002). Relationships were unchanged after controlling for T2 lesion volume and fatigue. Conclusion: Consistent mood–cognition relationships were identified in two independent cohorts of MS patients, suggesting that cognitive correlates of anxiety and depression are separable. This dissociation may support more precise models to inform treatment development. Treatment of mood symptoms may mitigate effects on cognition and/or treatment of cognition may mitigate effects on mood.
KW - Anxiety
KW - cognition
KW - depression
KW - memory impairment
KW - multiple sclerosis
UR - http://www.scopus.com/inward/record.url?scp=85068219167&partnerID=8YFLogxK
U2 - 10.1177/1352458519860319
DO - 10.1177/1352458519860319
M3 - Article
C2 - 31233379
AN - SCOPUS:85068219167
VL - 26
SP - 1247
EP - 1255
JO - Multiple Sclerosis Journal
JF - Multiple Sclerosis Journal
SN - 1352-4585
IS - 10
ER -