TY - JOUR
T1 - Dissecting the effects of spinal fusion and deformity magnitude on quality of life in patients with adolescent idiopathic scoliosis
AU - Tsutsui, Shunji
AU - Pawelek, Jeff
AU - Bastrom, Tracey
AU - Lenke, Lawrence
AU - Lowe, Thomas
AU - Betz, Randal
AU - Clements, David
AU - Newton, Peter O.
PY - 2009/8
Y1 - 2009/8
N2 - STUDY DESIGN. A retrospective review of scores from the Scoliosis Research Society outcomes instrument (SRS-24 questionnaire). OBJECTIVE. To quantify the isolated effects of spinal fusion and deformity magnitude on quality of life in patients with adolescent idiopathic scoliosis (AIS). SUMMARY OF BACKGROUND DATA. Significant improvements in 2-year postoperative SRS-24 questionnaire scores have been reported despite the loss of spinal motion due to instrumentation and arthrodesis. As deformity reduction may influence patient perception, it has been difficult to isolate the effect of spinal fusion on quality of life after scoliosis surgery. METHODS. SRS-24 scores were compared between 3 cohorts of AIS patients (preoperative, postoperative, and nonoperative) using an ANOVA (P < 0.05) to determine the isolated effects of spinal fusion and deformity magnitude. Preoperative SRS-24 scores were collected from a group of patients with preoperative major Cobb angles greater than 40°(n = 194). Postoperative SRS-24 scores were collected from patients with preoperative major Cobb angles greater than 40°and 2-year postoperative major Cobb angles between 20°and 40°(n = 196). Finally, SRS-24 scores were collected from a nonoperative group of patients with major Cobb angles between 20°and 40°(n = 112). RESULTS. Spinal fusion was found to have a negative isolated effect on the Activity domain (-0.3) and on the Total score (-0.2) (P = 0.001) of the SRS-24 questionnaire (score range: 1-5). A smaller deformity magnitude, on the other hand, was found to have a significantly positive isolated effect on all 4 preoperative domains (P < 0.001) and on the Total score (P < 0.001). The combined effect of surgery (spinal fusion and deformity correction) was found to be significantly positive for the Total score (P < 0.001) and for the domains of Pain, Self-Image, and Function (P < 0.001). CONCLUSION. Spinal fusion has an isolated negative effect on AIS patients' quality of life (Total score) mostly due to a decrease in scores of the Activity domain. The overall positive effect of surgery depends on the individual effects of spinal fusion (slight reduction in quality of life) and deformity reduction (modest improvement in quality of life).
AB - STUDY DESIGN. A retrospective review of scores from the Scoliosis Research Society outcomes instrument (SRS-24 questionnaire). OBJECTIVE. To quantify the isolated effects of spinal fusion and deformity magnitude on quality of life in patients with adolescent idiopathic scoliosis (AIS). SUMMARY OF BACKGROUND DATA. Significant improvements in 2-year postoperative SRS-24 questionnaire scores have been reported despite the loss of spinal motion due to instrumentation and arthrodesis. As deformity reduction may influence patient perception, it has been difficult to isolate the effect of spinal fusion on quality of life after scoliosis surgery. METHODS. SRS-24 scores were compared between 3 cohorts of AIS patients (preoperative, postoperative, and nonoperative) using an ANOVA (P < 0.05) to determine the isolated effects of spinal fusion and deformity magnitude. Preoperative SRS-24 scores were collected from a group of patients with preoperative major Cobb angles greater than 40°(n = 194). Postoperative SRS-24 scores were collected from patients with preoperative major Cobb angles greater than 40°and 2-year postoperative major Cobb angles between 20°and 40°(n = 196). Finally, SRS-24 scores were collected from a nonoperative group of patients with major Cobb angles between 20°and 40°(n = 112). RESULTS. Spinal fusion was found to have a negative isolated effect on the Activity domain (-0.3) and on the Total score (-0.2) (P = 0.001) of the SRS-24 questionnaire (score range: 1-5). A smaller deformity magnitude, on the other hand, was found to have a significantly positive isolated effect on all 4 preoperative domains (P < 0.001) and on the Total score (P < 0.001). The combined effect of surgery (spinal fusion and deformity correction) was found to be significantly positive for the Total score (P < 0.001) and for the domains of Pain, Self-Image, and Function (P < 0.001). CONCLUSION. Spinal fusion has an isolated negative effect on AIS patients' quality of life (Total score) mostly due to a decrease in scores of the Activity domain. The overall positive effect of surgery depends on the individual effects of spinal fusion (slight reduction in quality of life) and deformity reduction (modest improvement in quality of life).
KW - Adolescent idiopathic scoliosis
KW - Effect of deformity correction
KW - Effect of spinal fusion
KW - Quality of life
UR - http://www.scopus.com/inward/record.url?scp=69749105625&partnerID=8YFLogxK
U2 - 10.1097/BRS.0b013e3181b2008f
DO - 10.1097/BRS.0b013e3181b2008f
M3 - Article
C2 - 19680091
AN - SCOPUS:69749105625
SN - 0362-2436
VL - 34
SP - E653-E658
JO - Spine
JF - Spine
IS - 18
ER -