TY - JOUR
T1 - Disrupted computations of social control in individuals with obsessive-compulsive and misophonia symptoms
AU - Banker, Sarah M.
AU - Na, Soojung
AU - Beltrán, Jacqueline
AU - Koenigsberg, Harold W.
AU - Foss-Feig, Jennifer H.
AU - Gu, Xiaosi
AU - Schiller, Daniela
N1 - Funding Information:
This work was supported by funding from the Ream Foundation—Misophonia Research Fund and internal institutional funding from the Icahn School of Medicine at Mount Sinai. S.M.B. is supported by the National Institute of Mental Health (Grant No. R01MH122611) and the Beatrice and Samuel A. Seaver Foundation (Fellowship). H.W.K. is supported by the National Institute of Mental Health (Grant Nos R01MH109730, R01MH123069, and R61MH125130) and the Veterans Affairs Medical Center. J.F.-F. is supported by the National Institute of Mental Health (Grant Nos R01MH122611 and R01MH119172), the National Institute of Neurological Disorders and Stroke (Grant No. R01NS105845), the Simons Foundation Autism Research Initiative, and the Seaver Foundation Rare Disease Program. X.G. is supported by the National Institute of Mental Health (Grant Nos R01MH122611, R01MH123069, and R21MH120789), and the Simons Foundation Autism Research Initiative. D.S. is supported by the National Institute of Mental Health (Grant Nos R01MH122611, R01MH123069, and R21MH120789), the Simons Foundation Autism Research Initiative, and the Ream Foundation. Conceptualization, D.S. X.G. J.F.-F. and H.W.K.; Methodology, S.M.B. D.S. X.G. and J.F.-F.; Investigation, S.M.B. S.N. and J.B.; Writing—Original Draft, S.M.B.; Writing—Review & Editing, S.M.B. S.N. J.B. D.S. X.G. J.F.-F.; Funding Acquisition, D.S. and X.G.; Resources, S.N; Supervision, D.S. X.G. J.F.-F, and H.W.K. The authors declare no competing interests in relation to this work. We worked to ensure gender balance in the recruitment of human subjects. We worked to ensure ethnic or other types of diversity in the recruitment of human subjects. We worked to ensure that the study questionnaires were prepared in an inclusive way. One or more of the authors of this paper self-identifies as an underrepresented ethnic minority in science. One or more of the authors of this paper received support from a program designed to increase minority representation in science.
Publisher Copyright:
© 2022 The Author(s)
PY - 2022/7/15
Y1 - 2022/7/15
N2 - Misophonia is a disorder in which certain sounds produced by other people lead to intense negative reactions. It remains unknown how misophonia relates to other psychiatric conditions or impairments. To identify latent constructs underlying symptoms, we conducted a factor analysis consisting of items from questionnaires assessing symptoms of misophonia and other psychiatric conditions. One thousand forty-two participants completed the questionnaires and a social exchange task in which they either could (“controllable”) or could not (“uncontrollable”) influence future monetary offers from other people. Misophonia and obsessive-compulsive (OC) symptoms loaded onto the same factor. Compared with individuals with low Miso-OC factor scores, individuals with high scores reported higher perceived controllability of their social interactions during the uncontrollable condition and stronger aversion to social norm violations in the uncontrollable compared with the controllable condition. Together, these results suggest misophonia, and OC symptoms share a latent psychiatric dimension characterized by aberrant computations of social controllability.
AB - Misophonia is a disorder in which certain sounds produced by other people lead to intense negative reactions. It remains unknown how misophonia relates to other psychiatric conditions or impairments. To identify latent constructs underlying symptoms, we conducted a factor analysis consisting of items from questionnaires assessing symptoms of misophonia and other psychiatric conditions. One thousand forty-two participants completed the questionnaires and a social exchange task in which they either could (“controllable”) or could not (“uncontrollable”) influence future monetary offers from other people. Misophonia and obsessive-compulsive (OC) symptoms loaded onto the same factor. Compared with individuals with low Miso-OC factor scores, individuals with high scores reported higher perceived controllability of their social interactions during the uncontrollable condition and stronger aversion to social norm violations in the uncontrollable compared with the controllable condition. Together, these results suggest misophonia, and OC symptoms share a latent psychiatric dimension characterized by aberrant computations of social controllability.
KW - Behavioral neuroscience
KW - Biological sciences
KW - Clinical neuroscience
KW - Neuroscience
KW - Sensory neuroscience
UR - http://www.scopus.com/inward/record.url?scp=85133202431&partnerID=8YFLogxK
U2 - 10.1016/j.isci.2022.104617
DO - 10.1016/j.isci.2022.104617
M3 - Article
AN - SCOPUS:85133202431
VL - 25
JO - iScience
JF - iScience
SN - 2589-0042
IS - 7
M1 - 104617
ER -