TY - JOUR
T1 - Disrupted circuits in mouse models of autism spectrum disorder and intellectual disability
AU - Golden, Carla EM
AU - Buxbaum, Joseph D.
AU - De Rubeis, Silvia
N1 - Funding Information:
This work was supported by the Seaver Foundation (to SDR, CEMG, and JDB), and the grants F31 MH115656-01 (to CEMG), R01MH093725 (to JDB), and R01MH101584 (to JDB). Carla Golden is a Seaver Graduate Fellow.
Publisher Copyright:
© 2017 Elsevier Ltd
PY - 2018/2
Y1 - 2018/2
N2 - Autism spectrum disorder (ASD) and intellectual disability (ID) are caused by a wide range of genetic mutations, a significant fraction of which reside in genes important for synaptic function. Studies have found that sensory, prefrontal, hippocampal, cerebellar, and striatal regions, as well as the circuits that connect them, are perturbed in mouse models of ASD and ID. Dissecting the disruptions in morphology and activity in these neural circuits might help us to understand the shared risk between the two disorders as well as their clinical heterogeneity. Treatments that target the balance between excitation and inhibition in these regions are able to reverse pathological phenotypes, elucidating this deficit as a commonality across models and opening new avenues for intervention.
AB - Autism spectrum disorder (ASD) and intellectual disability (ID) are caused by a wide range of genetic mutations, a significant fraction of which reside in genes important for synaptic function. Studies have found that sensory, prefrontal, hippocampal, cerebellar, and striatal regions, as well as the circuits that connect them, are perturbed in mouse models of ASD and ID. Dissecting the disruptions in morphology and activity in these neural circuits might help us to understand the shared risk between the two disorders as well as their clinical heterogeneity. Treatments that target the balance between excitation and inhibition in these regions are able to reverse pathological phenotypes, elucidating this deficit as a commonality across models and opening new avenues for intervention.
UR - http://www.scopus.com/inward/record.url?scp=85036664267&partnerID=8YFLogxK
U2 - 10.1016/j.conb.2017.11.006
DO - 10.1016/j.conb.2017.11.006
M3 - Review article
C2 - 29222989
AN - SCOPUS:85036664267
SN - 0959-4388
VL - 48
SP - 106
EP - 112
JO - Current Opinion in Neurobiology
JF - Current Opinion in Neurobiology
ER -