Disparities in racial and ethnic representation in stem cell clinical trials

Irena Parvanova, Joseph Finkelstein

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

6 Scopus citations

Abstract

ClinicalTrials.gov (CTG) provides integrated access to structured records of thousands of randomized clinical trials (RCT). CTG functionality allows download of the entire dataset in XML format for further knowledge discovery and analytics. This study represents an instructive use case of utilizing this functionality for identifying patient representation disparities in stem cell RCTs. The goal of this study was to determine the racial and ethnic composition of stem cell clinical trials and to identify potential disparities in minority representation. The clinical trial registration portal ClinicalTrials.gov was queried to identify stem cell trials and to compare their racial and ethnic composition to the US population data. Based on our analysis of 248 available trials, we have concluded that not all races and ethnicities are adequately represented in US stem cell trials; thus, concerted efforts are warranted for more inclusive representation of minorities in future stem cell trials.

Original languageEnglish
Title of host publicationTHE IMPORTANCE OF HEALTH INFORMATICS IN PUBLIC HEALTH DURING A PANDEMIC
EditorsJohn Mantas, Arie Hasman, Mowafa S. Househ, Parisis Gallos, Emmanouil Zoulias
PublisherIOS Press
Pages358-361
Number of pages4
ISBN (Electronic)9781643680927
DOIs
StatePublished - 2020

Publication series

NameStudies in Health Technology and Informatics
Volume272
ISSN (Print)0926-9630
ISSN (Electronic)1879-8365

Keywords

  • Discrepancy
  • Ethnicity
  • Race
  • Stem cell therapy

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