@article{a8dc3377721b41409c45b958a01c06be,
title = "Dishevelled activates JNK and discriminates between JNK pathways in planar polarity and wingless signaling",
abstract = "Frizzled family proteins have been described as receptors of Wnt signaling molecules. In Drosophila, the two known Frizzled proteins are associated with distinct developmental processes. Genesis of epithelial planar polarity requires Frizzled, whereas Dfz2 affects morphogenesis by wingless-mediated signaling. Dishevelled is required in both signaling pathways. Here, we use genetic and overexpression assays to show that Dishevelled activates JNK cascades. Rescue analysis reveals different protein domain requirements in Dishevelled for the two pathways; the C-terminal DEP domain is essential to rescue planar polarity defects and induce JNK signaling. Furthermore, the planar polarity-specific dsh1 allele is mutated in the DEP domain. Our results indicate that different Wnt/Fz signals activate distinct intracellular pathways, and Dishevelled discriminates among them by distinct domain interactions.",
author = "Michael Boutros and Nuria Paricio and Strutt, \{David I.\} and Marek Mlodzik",
note = "Funding Information: We are grateful to Jeff Axelrod and Norbert Perrimon for sharing unpublished results and to Rick Fehon for fly strains prior to publication. We thank Roel Nusse for Dsh cDNA clones; Konrad Basler, Ken Cadigan, Mark Peifer, and Clive Wilson for fly strains; and Tony Ip for information regarding other JNKs. We would like to thank Sirpa Leppae and Dirk Bohmann for stimulating discussions, Ann-Marie Voie for Drosophila embryo injections, and Ursula Weber for the gift of the sev-RhoA V14 flies. We are grateful to P. Becker, D. Bohmann, S. Cohen, C. Blaumueller, and members of the Mlodzik lab for helpful comments on the manuscript. M. B. was supported by a fellowship from the Boehringer Ingelheim Fonds and N. P. by a Marie Curie fellowship from the EEC.",
year = "1998",
month = jul,
day = "10",
doi = "10.1016/S0092-8674(00)81226-X",
language = "English",
volume = "94",
pages = "109--118",
journal = "Cell",
issn = "0092-8674",
publisher = "Elsevier B.V.",
number = "1",
}