Disease incidence and longevity are unaltered by dietary antioxidant supplementation initiated during middle age in C57BL/6 mice

R. D. Lipman, R. T. Bronson, D. Wu, D. E. Smith, R. Prior, G. Cao, S. N. Han, K. R. Martin, S. N. Meydani, M. Meydani

Research output: Contribution to journalArticlepeer-review

87 Scopus citations

Abstract

The ability of augmented antioxidant consumption to alter disease incidence, lesion burden and/or longevity was studied in adult male C57BL/6 mice. Mice were fed modified AIN76 diet or modified AIN76 supplemented with vitamin E, glutathione (GSH), vitamin E and GSH, melatonin or strawberry extract starting at 18 months of age. All the mice in this study were heavier than reference populations of male C57BL/6 mice fed NIH-07 or NIH-31, which were maintained without a mid-life change in diet. Fatty liver, focal kidney atrophy and proteinacious casts in the renal tubules were observed more frequently in this study population than in the reference populations. Lesion burden and incidence of specific lesions observed amongst the various groups in this study did not differ. There were no differences observed for longevity of any of the study groups. The longevity observed in this study was similar to that previously reported for male C57BL/6 mice. Thus, diet supplementation with antioxidants initiated during middle age did not appear to affect age-associated lesions patterns, lesion burden or longevity for ad libitum fed male C57BL/6 mice.

Original languageEnglish
Pages (from-to)269-284
Number of pages16
JournalMechanisms of Ageing and Development
Volume103
Issue number3
DOIs
StatePublished - 15 Jul 1998
Externally publishedYes

Keywords

  • Aging
  • Antioxidant
  • Lesions
  • Longevity
  • Mice
  • Nutrition

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