Discrepancies of polygenic effects on symptom dimensions between adolescents and adults with ADHD

Wenhao Jiang; Kelly Rootes-Murdy; Kuaikuai Duan; Gido Schoenmacker; Pieter J. Hoekstra; Catharina A. Hartman; Jaap Oosterlaan; Dirk Heslenfeld; Barbara Franke; Emma Sprooten; Jan Buitelaar; Alejandro Arias-Vasquez; Jingyu Liu; Jessica A. Turner

doi:10.1016/j.pscychresns.2021.111282

Discrepancies of polygenic effects on symptom dimensions between adolescents and adults with ADHD

Wenhao Jiang, Kelly Rootes-Murdy, Kuaikuai Duan, Gido Schoenmacker, Pieter J. Hoekstra, Catharina A. Hartman, Jaap Oosterlaan, Dirk Heslenfeld, Barbara Franke, Emma Sprooten, Jan Buitelaar, Alejandro Arias-Vasquez, Jingyu Liu, Jessica A. Turner

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3 Scopus citations

Abstract

A significant proportion of individuals with attention-deficit/hyperactivity disorder (ADHD) show persistence into adulthood. The genetic and neural correlates of ADHD in adolescents versus adults remain poorly characterized. We investigated ADHD polygenic risk score (PRS) in relation to previously identified gray matter (GM) patterns, neurocognitive, and symptom findings in the same ADHD sample (462 adolescents & 422 adults from the NeuroIMAGE and IMpACT cohorts). Significant effects of ADHD PRS were found on hyperactivity and impulsivity symptoms in adolescents, hyperactivity symptom in adults, but not GM volume components. A distinct PRS effect between adolescents and adults on individual ADHD symptoms is suggested.

Original language	English
Article number	111282
Journal	Psychiatry Research - Neuroimaging
Volume	311
DOIs	https://doi.org/10.1016/j.pscychresns.2021.111282
State	Published - 30 May 2021
Externally published	Yes

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Jiang, W., Rootes-Murdy, K., Duan, K., Schoenmacker, G., Hoekstra, P. J., Hartman, C. A., Oosterlaan, J., Heslenfeld, D., Franke, B., Sprooten, E., Buitelaar, J., Arias-Vasquez, A., Liu, J., & Turner, J. A. (2021). Discrepancies of polygenic effects on symptom dimensions between adolescents and adults with ADHD. Psychiatry Research - Neuroimaging, 311, Article 111282. https://doi.org/10.1016/j.pscychresns.2021.111282

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title = "Discrepancies of polygenic effects on symptom dimensions between adolescents and adults with ADHD",

abstract = "A significant proportion of individuals with attention-deficit/hyperactivity disorder (ADHD) show persistence into adulthood. The genetic and neural correlates of ADHD in adolescents versus adults remain poorly characterized. We investigated ADHD polygenic risk score (PRS) in relation to previously identified gray matter (GM) patterns, neurocognitive, and symptom findings in the same ADHD sample (462 adolescents & 422 adults from the NeuroIMAGE and IMpACT cohorts). Significant effects of ADHD PRS were found on hyperactivity and impulsivity symptoms in adolescents, hyperactivity symptom in adults, but not GM volume components. A distinct PRS effect between adolescents and adults on individual ADHD symptoms is suggested.",

author = "Wenhao Jiang and Kelly Rootes-Murdy and Kuaikuai Duan and Gido Schoenmacker and Hoekstra, {Pieter J.} and Hartman, {Catharina A.} and Jaap Oosterlaan and Dirk Heslenfeld and Barbara Franke and Emma Sprooten and Jan Buitelaar and Alejandro Arias-Vasquez and Jingyu Liu and Turner, {Jessica A.}",

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doi = "10.1016/j.pscychresns.2021.111282",

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Jiang, W, Rootes-Murdy, K, Duan, K, Schoenmacker, G, Hoekstra, PJ, Hartman, CA, Oosterlaan, J, Heslenfeld, D, Franke, B, Sprooten, E, Buitelaar, J, Arias-Vasquez, A, Liu, J & Turner, JA 2021, 'Discrepancies of polygenic effects on symptom dimensions between adolescents and adults with ADHD', Psychiatry Research - Neuroimaging, vol. 311, 111282. https://doi.org/10.1016/j.pscychresns.2021.111282

TY - JOUR

T1 - Discrepancies of polygenic effects on symptom dimensions between adolescents and adults with ADHD

AU - Jiang, Wenhao

AU - Rootes-Murdy, Kelly

AU - Duan, Kuaikuai

AU - Schoenmacker, Gido

AU - Hoekstra, Pieter J.

AU - Hartman, Catharina A.

AU - Oosterlaan, Jaap

AU - Heslenfeld, Dirk

AU - Franke, Barbara

AU - Sprooten, Emma

AU - Buitelaar, Jan

AU - Arias-Vasquez, Alejandro

AU - Liu, Jingyu

AU - Turner, Jessica A.

PY - 2021/5/30

Y1 - 2021/5/30

N2 - A significant proportion of individuals with attention-deficit/hyperactivity disorder (ADHD) show persistence into adulthood. The genetic and neural correlates of ADHD in adolescents versus adults remain poorly characterized. We investigated ADHD polygenic risk score (PRS) in relation to previously identified gray matter (GM) patterns, neurocognitive, and symptom findings in the same ADHD sample (462 adolescents & 422 adults from the NeuroIMAGE and IMpACT cohorts). Significant effects of ADHD PRS were found on hyperactivity and impulsivity symptoms in adolescents, hyperactivity symptom in adults, but not GM volume components. A distinct PRS effect between adolescents and adults on individual ADHD symptoms is suggested.

AB - A significant proportion of individuals with attention-deficit/hyperactivity disorder (ADHD) show persistence into adulthood. The genetic and neural correlates of ADHD in adolescents versus adults remain poorly characterized. We investigated ADHD polygenic risk score (PRS) in relation to previously identified gray matter (GM) patterns, neurocognitive, and symptom findings in the same ADHD sample (462 adolescents & 422 adults from the NeuroIMAGE and IMpACT cohorts). Significant effects of ADHD PRS were found on hyperactivity and impulsivity symptoms in adolescents, hyperactivity symptom in adults, but not GM volume components. A distinct PRS effect between adolescents and adults on individual ADHD symptoms is suggested.

UR - http://www.scopus.com/inward/record.url?scp=85103113221&partnerID=8YFLogxK

U2 - 10.1016/j.pscychresns.2021.111282

DO - 10.1016/j.pscychresns.2021.111282

M3 - Article

C2 - 33780745

AN - SCOPUS:85103113221

SN - 0925-4927

VL - 311

JO - Psychiatry Research - Neuroimaging

JF - Psychiatry Research - Neuroimaging

M1 - 111282

ER -

Discrepancies of polygenic effects on symptom dimensions between adolescents and adults with ADHD

Abstract

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