TY - JOUR
T1 - Discoid lupus erythematosus and cicatrizing conjunctivitis
T2 - Clinicopathologic study of two cases
AU - Thorne, Jennifer E.
AU - Jabs, Douglas A.
AU - Nikolskaia, Olga
AU - Anhalt, Grant
AU - Nousari, H. Carlos
N1 - Funding Information:
Supported in part by grants from the NIH, K23 EY13707 (Dr. Thorne) and K24 EY00405 (Dr. Jabs). Dr. Jabs is the recipient of the Research to Prevent Blindness Senior Investigator Award.
PY - 2002/12
Y1 - 2002/12
N2 - Background: Discoid lupus erythematosus (DLE) demonstrates both cutaneous and mucosal manifestations. Mucosal involvement is typically limited to the oral and anogenital mucosa. Conjunctival involvement in DLE is rare, especially in the absence of accompanying cutaneous disease. Objective: We describe the clinical and immunopathologic features of two cases of cicatrizing conjunctivitis due to DLE. Methods: In each patient, the clinical, immunopathologic, and serologic features were reviewed and the results recorded. Results: Both patients presented with cicatrizing conjunctivitis suggestive of mucous membrane pemphigoid. Patient 1 had no history of typical DLE skin lesions. Patient 2 had a history of cutaneous and oral DLE prior to presentation. Histologic, electron microscopic, and direct immunofluorescence examination confirmed the diagnosis DLE in both patients. Conclusion: In patients presenting with cicatrizing conjunctivitis, DLE should be considered in the differential diagnosis. Performing appropriate investigations to distinguish conjunctival DLE from other autoimmune diseases with conjunctival involvement such as mucous membrane pemphigoid is critical in selecting an appropriate treatment regimen, in offering an accurate prognosis, and in monitoring for signs and symptoms of disease progression.
AB - Background: Discoid lupus erythematosus (DLE) demonstrates both cutaneous and mucosal manifestations. Mucosal involvement is typically limited to the oral and anogenital mucosa. Conjunctival involvement in DLE is rare, especially in the absence of accompanying cutaneous disease. Objective: We describe the clinical and immunopathologic features of two cases of cicatrizing conjunctivitis due to DLE. Methods: In each patient, the clinical, immunopathologic, and serologic features were reviewed and the results recorded. Results: Both patients presented with cicatrizing conjunctivitis suggestive of mucous membrane pemphigoid. Patient 1 had no history of typical DLE skin lesions. Patient 2 had a history of cutaneous and oral DLE prior to presentation. Histologic, electron microscopic, and direct immunofluorescence examination confirmed the diagnosis DLE in both patients. Conclusion: In patients presenting with cicatrizing conjunctivitis, DLE should be considered in the differential diagnosis. Performing appropriate investigations to distinguish conjunctival DLE from other autoimmune diseases with conjunctival involvement such as mucous membrane pemphigoid is critical in selecting an appropriate treatment regimen, in offering an accurate prognosis, and in monitoring for signs and symptoms of disease progression.
KW - Cicatrizing conjunctivitis
KW - Direct immunofluorescence
KW - Discoid lupus erythematosus
UR - http://www.scopus.com/inward/record.url?scp=0037998865&partnerID=8YFLogxK
U2 - 10.1076/ocii.10.4.287.15595
DO - 10.1076/ocii.10.4.287.15595
M3 - Article
C2 - 12854037
AN - SCOPUS:0037998865
SN - 0927-3948
VL - 10
SP - 287
EP - 292
JO - Ocular Immunology and Inflammation
JF - Ocular Immunology and Inflammation
IS - 4
ER -