Direct comparison of mice null for liver or intestinal fatty acid-binding proteins reveals highly divergent phenotypic responses to high fat feeding

Angela M. Gajda, Yin Xiu Zhou, Luis B. Agellon, Susan K. Fried, Sarala Kodukula, Walter Fortson, Khamoshi Patel, Judith Storch

Research output: Contribution to journalArticlepeer-review

40 Scopus citations

Abstract

Background: Intestinal and liver fatty acid-binding proteins (IFABP and LFABP) are coexpressed in the enterocyte, but their individual functions are not known. Results: High fat feeding promotes different phenotypes in IFABP- and LFABP-null mice. Conclusion: IFABP and LFABP have unique intracellular functions, which in turn produce divergent whole body effects. Significance: Enterocyte FABP ablation modulates intestinal lipid metabolism, which contributes to altered systemic energy homeostasis.

Original languageEnglish
Pages (from-to)30330-30344
Number of pages15
JournalJournal of Biological Chemistry
Volume288
Issue number42
DOIs
StatePublished - 18 Oct 2013
Externally publishedYes

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