Dipyridamole in the treatment of angina pectoris: A meta-analysis

H. S. Sacks, J. Berrier, R. Nagalingham, T. C. Chalmers

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

A meta-analysis of 11 randomized trials published between 1960 and 1970 was performed to re-evaluate data on the efficacy of dipyridamole in the prevention and treatment of chronic angina pectoris. Three trials significantly favored drug vs placebo, four showed a trend towards drug vs placebo, two showed no difference and two showed a trend towards placebo vs drug. The combined results of these 11 trials showed a statistically significant improvement with dipyridamole. Although this result should be viewed with caution because of methodologic variations in the studies, the available evidence appears to suggest that dipyridamole may have a beneficial effect, and that it may have been prematurely discarded in the treatment of angina pectoris.

Original languageEnglish
Pages (from-to)35-42
Number of pages8
JournalThrombosis Research
Volume57
Issue numberSUPPL. 3
DOIs
StatePublished - 1990

Keywords

  • Persantine, not animal
  • angina pectoris
  • dipyridamole
  • meta-analysis

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