Diminished cerebral metabolic response to motor stimulation in schizophrenics: a PET study

Wilfried Guenther; Jonathan D. Brodie; Elsa J. Bartlett; Stephen L. Dewey; Fritz A. Henn; Nora D. Volkow; Kenneth Alper; Adam Wolkin; Robert Cancro; Alfred P. Wolf

doi:10.1007/BF02191884

Diminished cerebral metabolic response to motor stimulation in schizophrenics: a PET study

Wilfried Guenther, Jonathan D. Brodie, Elsa J. Bartlett, Stephen L. Dewey, Fritz A. Henn, Nora D. Volkow, Kenneth Alper, Adam Wolkin, Robert Cancro, Alfred P. Wolf

Research output: Contribution to journal › Article › peer-review

44 Scopus citations

Abstract

Positron emission tomography (PET) and the deoxyglucose method were used to measure cerebral metabolism in 14 normals and 13 schizophrenics at rest and during performance of simple and complex finger-movement sequences. The normals, but not the schizophrenics, showed significant metabolic activation in mesial frontal and contralateral sensorimotor and premotor regions during the complex movement. The relative metabolism of schizophrenics was significantly lower than normal in frontal regions and higher than normal in thalamus and basal ganglia under all scanning conditions. The results suggest that schizophrenics may have a brain dysfunction which limits their capacity to produce a focal metabolic response to stimulation in several functionally distinct brain regions.

Original language	English
Pages (from-to)	115-125
Number of pages	11
Journal	European Archives of Psychiatry and Clinical Neuroscience
Volume	244
Issue number	3
DOIs	https://doi.org/10.1007/BF02191884
State	Published - Sep 1994
Externally published	Yes

Keywords

Cortical activation in schizophrenia
Motor dysfunction
PET in schizophrenia
Schizophrenic brain dysfunction

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10.1007/BF02191884

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title = "Diminished cerebral metabolic response to motor stimulation in schizophrenics: a PET study",

abstract = "Positron emission tomography (PET) and the deoxyglucose method were used to measure cerebral metabolism in 14 normals and 13 schizophrenics at rest and during performance of simple and complex finger-movement sequences. The normals, but not the schizophrenics, showed significant metabolic activation in mesial frontal and contralateral sensorimotor and premotor regions during the complex movement. The relative metabolism of schizophrenics was significantly lower than normal in frontal regions and higher than normal in thalamus and basal ganglia under all scanning conditions. The results suggest that schizophrenics may have a brain dysfunction which limits their capacity to produce a focal metabolic response to stimulation in several functionally distinct brain regions.",

keywords = "Cortical activation in schizophrenia, Motor dysfunction, PET in schizophrenia, Schizophrenic brain dysfunction",

author = "Wilfried Guenther and Brodie, {Jonathan D.} and Bartlett, {Elsa J.} and Dewey, {Stephen L.} and Henn, {Fritz A.} and Volkow, {Nora D.} and Kenneth Alper and Adam Wolkin and Robert Cancro and Wolf, {Alfred P.}",

year = "1994",

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doi = "10.1007/BF02191884",

language = "English",

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pages = "115--125",

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TY - JOUR

T1 - Diminished cerebral metabolic response to motor stimulation in schizophrenics

T2 - a PET study

AU - Guenther, Wilfried

AU - Brodie, Jonathan D.

AU - Bartlett, Elsa J.

AU - Dewey, Stephen L.

AU - Henn, Fritz A.

AU - Volkow, Nora D.

AU - Alper, Kenneth

AU - Wolkin, Adam

AU - Cancro, Robert

AU - Wolf, Alfred P.

PY - 1994/9

Y1 - 1994/9

N2 - Positron emission tomography (PET) and the deoxyglucose method were used to measure cerebral metabolism in 14 normals and 13 schizophrenics at rest and during performance of simple and complex finger-movement sequences. The normals, but not the schizophrenics, showed significant metabolic activation in mesial frontal and contralateral sensorimotor and premotor regions during the complex movement. The relative metabolism of schizophrenics was significantly lower than normal in frontal regions and higher than normal in thalamus and basal ganglia under all scanning conditions. The results suggest that schizophrenics may have a brain dysfunction which limits their capacity to produce a focal metabolic response to stimulation in several functionally distinct brain regions.

AB - Positron emission tomography (PET) and the deoxyglucose method were used to measure cerebral metabolism in 14 normals and 13 schizophrenics at rest and during performance of simple and complex finger-movement sequences. The normals, but not the schizophrenics, showed significant metabolic activation in mesial frontal and contralateral sensorimotor and premotor regions during the complex movement. The relative metabolism of schizophrenics was significantly lower than normal in frontal regions and higher than normal in thalamus and basal ganglia under all scanning conditions. The results suggest that schizophrenics may have a brain dysfunction which limits their capacity to produce a focal metabolic response to stimulation in several functionally distinct brain regions.

KW - Cortical activation in schizophrenia

KW - Motor dysfunction

KW - PET in schizophrenia

KW - Schizophrenic brain dysfunction

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JO - European Archives of Psychiatry and Clinical Neuroscience

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Diminished cerebral metabolic response to motor stimulation in schizophrenics: a PET study

Abstract

Keywords

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