Diglyceryl lipase activity in mouse platelets

Richard C. Franson, William I. Rosenblum

Research output: Contribution to journalArticlepeer-review

Abstract

These studies reveal for the first time that mouse platelets have substantial diglyceryl lipase (DGL) activity (b38±29 nmols/hr/109 platelets) compared with human 37±56 mmols/hr/109 platelets) or rat platelets (25±11 nmols/hr/109 platelets). Our demonstration of the enzyme in rat platelets contrasts with the scant activity of DGL in that species as reported by others. The activity of DGL in mouse platelets was inhibited by RHC80267, an agent previously described as an inhibitor of DGL in dog and rat platelets.

Original languageEnglish
Pages (from-to)323-329
Number of pages7
JournalThrombosis Research
Volume36
Issue number4
DOIs
StatePublished - 15 Nov 1984
Externally publishedYes

Keywords

  • diglyceryl lipase inhibitor
  • human platelets
  • rat platelets

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