Diffusion tensor imaging in seven minutes: Determining trade-offs between spatial and directional resolution

Neda Jahanshad; Liang Zhan; Matt A. Bernstein; Bret J. Borowski; Clifford R. Jack; Arthur W. Toga; Paul M. Thompson

doi:10.1109/ISBI.2010.5490200

Diffusion tensor imaging in seven minutes: Determining trade-offs between spatial and directional resolution

Neda Jahanshad, Liang Zhan, Matt A. Bernstein, Bret J. Borowski, Clifford R. Jack, Arthur W. Toga, Paul M. Thompson

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

23 Scopus citations

Abstract

Imaging protocols must obtain maximum information under tight time constraints, to minimize patient discomfort or attrition, and motion artifacts. As part of a pilot study optimizing DTI sequences for the Alzheimer's Disease Neuroimaging Initiative, we scanned 8 subjects with 3 DTI protocols of equal duration at two time-points (48 scans). If scan duration is fixed, collecting more diffusion-sensitized gradient directions can increase angular resolution at the expense of spatial. We compared 7-minute sequences with 3.0(48), 2.7(41), and 2.5(37) mm isotropic voxels (directions), to assess (1) SNR; (2) bias in estimating fiber anisotropy; (3) reproducibility over time; (4) intersubject variance-relevant for group comparisons. Statistical maps revealed that higher angular resolutions gave more reproducible estimates; FA depended on voxel size, with a steeper dependency in more heterogeneous regions. The intermediate resolution gave best SNR. 2mm DTI scans are common, but improved angular resolution may add temporal stability, and benefits for tractography.

Original language	English
Title of host publication	2010 7th IEEE International Symposium on Biomedical Imaging
Subtitle of host publication	From Nano to Macro, ISBI 2010 - Proceedings
Pages	1161-1164
Number of pages	4
DOIs	https://doi.org/10.1109/ISBI.2010.5490200
State	Published - 2010
Externally published	Yes
Event	7th IEEE International Symposium on Biomedical Imaging: From Nano to Macro, ISBI 2010 - Rotterdam, Netherlands Duration: 14 Apr 2010 → 17 Apr 2010

Publication series

Name	2010 7th IEEE International Symposium on Biomedical Imaging: From Nano to Macro, ISBI 2010 - Proceedings

Conference

Conference	7th IEEE International Symposium on Biomedical Imaging: From Nano to Macro, ISBI 2010
Country/Territory	Netherlands
City	Rotterdam
Period	14/04/10 → 17/04/10

Keywords

Angular resolution
Diffusion tensor imaging (DTI)
Imaging protocols
Signal to noise
Spatial resolution

Access to Document

10.1109/ISBI.2010.5490200

Cite this

Jahanshad, N., Zhan, L., Bernstein, M. A., Borowski, B. J., Jack, C. R., Toga, A. W., & Thompson, P. M. (2010). Diffusion tensor imaging in seven minutes: Determining trade-offs between spatial and directional resolution. In 2010 7th IEEE International Symposium on Biomedical Imaging: From Nano to Macro, ISBI 2010 - Proceedings (pp. 1161-1164). Article 5490200 (2010 7th IEEE International Symposium on Biomedical Imaging: From Nano to Macro, ISBI 2010 - Proceedings). https://doi.org/10.1109/ISBI.2010.5490200

Jahanshad, Neda ; Zhan, Liang ; Bernstein, Matt A. et al. / Diffusion tensor imaging in seven minutes : Determining trade-offs between spatial and directional resolution. 2010 7th IEEE International Symposium on Biomedical Imaging: From Nano to Macro, ISBI 2010 - Proceedings. 2010. pp. 1161-1164 (2010 7th IEEE International Symposium on Biomedical Imaging: From Nano to Macro, ISBI 2010 - Proceedings).

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title = "Diffusion tensor imaging in seven minutes: Determining trade-offs between spatial and directional resolution",

abstract = "Imaging protocols must obtain maximum information under tight time constraints, to minimize patient discomfort or attrition, and motion artifacts. As part of a pilot study optimizing DTI sequences for the Alzheimer's Disease Neuroimaging Initiative, we scanned 8 subjects with 3 DTI protocols of equal duration at two time-points (48 scans). If scan duration is fixed, collecting more diffusion-sensitized gradient directions can increase angular resolution at the expense of spatial. We compared 7-minute sequences with 3.0(48), 2.7(41), and 2.5(37) mm isotropic voxels (directions), to assess (1) SNR; (2) bias in estimating fiber anisotropy; (3) reproducibility over time; (4) intersubject variance-relevant for group comparisons. Statistical maps revealed that higher angular resolutions gave more reproducible estimates; FA depended on voxel size, with a steeper dependency in more heterogeneous regions. The intermediate resolution gave best SNR. 2mm DTI scans are common, but improved angular resolution may add temporal stability, and benefits for tractography.",

keywords = "Angular resolution, Diffusion tensor imaging (DTI), Imaging protocols, Signal to noise, Spatial resolution",

author = "Neda Jahanshad and Liang Zhan and Bernstein, {Matt A.} and Borowski, {Bret J.} and Jack, {Clifford R.} and Toga, {Arthur W.} and Thompson, {Paul M.}",

year = "2010",

doi = "10.1109/ISBI.2010.5490200",

language = "English",

isbn = "9781424441266",

series = "2010 7th IEEE International Symposium on Biomedical Imaging: From Nano to Macro, ISBI 2010 - Proceedings",

pages = "1161--1164",

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Jahanshad, N, Zhan, L, Bernstein, MA, Borowski, BJ, Jack, CR, Toga, AW & Thompson, PM 2010, Diffusion tensor imaging in seven minutes: Determining trade-offs between spatial and directional resolution. in 2010 7th IEEE International Symposium on Biomedical Imaging: From Nano to Macro, ISBI 2010 - Proceedings., 5490200, 2010 7th IEEE International Symposium on Biomedical Imaging: From Nano to Macro, ISBI 2010 - Proceedings, pp. 1161-1164, 7th IEEE International Symposium on Biomedical Imaging: From Nano to Macro, ISBI 2010, Rotterdam, Netherlands, 14/04/10. https://doi.org/10.1109/ISBI.2010.5490200

Diffusion tensor imaging in seven minutes: Determining trade-offs between spatial and directional resolution. / Jahanshad, Neda; Zhan, Liang; Bernstein, Matt A. et al.
2010 7th IEEE International Symposium on Biomedical Imaging: From Nano to Macro, ISBI 2010 - Proceedings. 2010. p. 1161-1164 5490200 (2010 7th IEEE International Symposium on Biomedical Imaging: From Nano to Macro, ISBI 2010 - Proceedings).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

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AU - Toga, Arthur W.

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AB - Imaging protocols must obtain maximum information under tight time constraints, to minimize patient discomfort or attrition, and motion artifacts. As part of a pilot study optimizing DTI sequences for the Alzheimer's Disease Neuroimaging Initiative, we scanned 8 subjects with 3 DTI protocols of equal duration at two time-points (48 scans). If scan duration is fixed, collecting more diffusion-sensitized gradient directions can increase angular resolution at the expense of spatial. We compared 7-minute sequences with 3.0(48), 2.7(41), and 2.5(37) mm isotropic voxels (directions), to assess (1) SNR; (2) bias in estimating fiber anisotropy; (3) reproducibility over time; (4) intersubject variance-relevant for group comparisons. Statistical maps revealed that higher angular resolutions gave more reproducible estimates; FA depended on voxel size, with a steeper dependency in more heterogeneous regions. The intermediate resolution gave best SNR. 2mm DTI scans are common, but improved angular resolution may add temporal stability, and benefits for tractography.

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Jahanshad N, Zhan L, Bernstein MA, Borowski BJ, Jack CR, Toga AW et al. Diffusion tensor imaging in seven minutes: Determining trade-offs between spatial and directional resolution. In 2010 7th IEEE International Symposium on Biomedical Imaging: From Nano to Macro, ISBI 2010 - Proceedings. 2010. p. 1161-1164. 5490200. (2010 7th IEEE International Symposium on Biomedical Imaging: From Nano to Macro, ISBI 2010 - Proceedings). doi: 10.1109/ISBI.2010.5490200

Diffusion tensor imaging in seven minutes: Determining trade-offs between spatial and directional resolution

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