Diffusion MRI in pediatric brain injury

Emily L. Dennis, Talin Babikian, Christopher C. Giza, Paul M. Thompson, Robert F. Asarnow

Research output: Contribution to journalArticlepeer-review

27 Scopus citations


Traumatic brain injury (TBI) is a major public health issue around the world and can be especially devastating in children as TBI can derail cognitive and social development. White matter (WM) is particularly vulnerable to disruption post-TBI, as myelination is ongoing during this period. Diffusion magnetic resonance imaging (dMRI) is a versatile modality for identifying and quantifying WM disruption and can detect diffuse axonal injury (DAI or TAI (traumatic axonal injury)). This review covers dMRI studies of pediatric TBI, including mild to severe injuries, and covering all periods post-injury. While there have been considerable advances in our understanding of pediatric TBI through the use of dMRI, there are still large gaps in our knowledge, which will be filled in by larger studies and more longitudinal studies. Heterogeneity post-injury is an obstacle in all TBI studies, but we expect that larger better-characterized samples will aid in identifying clinically meaningful subgroups within the pediatric TBI patient population.

Original languageEnglish
Pages (from-to)1683-1692
Number of pages10
JournalChild's Nervous System
Issue number10
StatePublished - 1 Oct 2017
Externally publishedYes


  • Concussion
  • Diffuse axonal injury
  • Diffusion MRI
  • Pediatric
  • Traumatic brain injury


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