Diffuse large B-Cell lymphoma associated with paraneoplastic Guillain–Barré syndrome: A diagnostic and therapeutic challenge

Brototo Deb, Manu R. Pandey, Pallawi Torka, Suchitra Sundaram

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Paraneoplastic neurological syndromes are a rare manifestation of non-Hodgkin lymphoma and can make treatment of these patients more challenging. We report the case of a 67-year-old man with high grade diffuse large B-cell lymphoma who presented with severe paraneoplastic Guillain–Barré syndrome. He was treated with intravenous immunoglobulin therapy and definitive chemoimmunotherapy, and achieved a full neurological recovery. In this report, we discuss various mechanisms of neurological dysfunction seen in lymphomas. Prompt oncologic treatment and immunotherapy for Guillain–Barré syndrome if instituted concurrently and early in the course of the disease can be associated with the best outcomes.

Original languageEnglish
JournalHematology/ Oncology and Stem Cell Therapy
DOIs
StateAccepted/In press - 2020
Externally publishedYes

Keywords

  • Guillain–Barré syndrome
  • Neuropathy
  • Non-Hodgkin lymphoma
  • Paraneoplastic syndromes

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