Diffuse infiltrative lymphocytosis syndrome: A disorder occurring in human immunodeficiency virus-1 infection that may present as a sicca syndrome

S. Itescu, R. Winchester

Research output: Contribution to journalReview articlepeer-review

107 Scopus citations

Abstract

Certain adults and children infected with the human immunodeficiency virus(HIV)-1 develop a disorder termed diffuse infiltrative lymphocytosis syndrome (DILS) that, although having certain similarities to classic Sjogren's syndrome, manifests distinctive clinical, serologic, immunologic, and immunogenetic characteristics. DILS is characterized by circulating CD8 lymphocytosis and apparently antigen-driven CD8 T-cell infiltration of salivary and lacrimal gland, pulmonary, renal, gastrointestinal, and breast tissues. The disproportionately greater degree of salivary gland enlargement and extraglandular disease, as well as the low frequency of autoantibodies and differing HLA associations, serve to distinguish DILS from classic Sjogren's syndrome.

Original languageEnglish
Pages (from-to)683-697
Number of pages15
JournalRheumatic Disease Clinics of North America
Volume18
Issue number3
StatePublished - 1992
Externally publishedYes

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