TY - JOUR
T1 - Diffuse Alveolar Hemorrhage after Allogeneic Hematopoietic Stem-Cell Transplantation
T2 - Treatment with Recombinant Factor VIIa
AU - Pastores, Stephen M.
AU - Papadopoulos, Esperanza
AU - Voigt, Louis
AU - Halpern, Neil A.
PY - 2003/12
Y1 - 2003/12
N2 - Diffuse alveolar hemorrhage (DAH) is a serious pulmonary complication that occurs in patients undergoing hematopoietic stem-cell transplantation (HSCT). Current management strategies are limited to corticosteroids, platelet transfusions, and mechanical ventilator support to treat acute respiratory failure. Recombinant factor VIIa (rFVIIa) is an approved agent for the treatment of bleeding in patients with hemophilia A or B and the presence of inhibitors. We report a case of DAH after allogeneic HSCT that failed standard therapy and was then successfully treated with rFVIIa.
AB - Diffuse alveolar hemorrhage (DAH) is a serious pulmonary complication that occurs in patients undergoing hematopoietic stem-cell transplantation (HSCT). Current management strategies are limited to corticosteroids, platelet transfusions, and mechanical ventilator support to treat acute respiratory failure. Recombinant factor VIIa (rFVIIa) is an approved agent for the treatment of bleeding in patients with hemophilia A or B and the presence of inhibitors. We report a case of DAH after allogeneic HSCT that failed standard therapy and was then successfully treated with rFVIIa.
KW - Allogeneic hematopoietic stem-cell transplantation
KW - Diffuse alveolar hemorrhage
KW - Recombinant factor VIIa
UR - http://www.scopus.com/inward/record.url?scp=0345732422&partnerID=8YFLogxK
U2 - 10.1378/chest.124.6.2400
DO - 10.1378/chest.124.6.2400
M3 - Article
C2 - 14665531
AN - SCOPUS:0345732422
SN - 0012-3692
VL - 124
SP - 2400
EP - 2403
JO - Chest
JF - Chest
IS - 6
ER -