Differentiating multiple sclerosis from other causes of demyelination using diffusion weighted imaging of the corpus callosum

Rebecca Straus Farber, Laetitia DeVilliers, Aaron Miller, Fred Lublin, Meng Law, Girish Fatterpekar, Bradley Delman, Thomas Naidich

Research output: Contribution to journalArticlepeer-review

12 Scopus citations

Abstract

Purpose: To compare diffusion weighted imaging metrics in gray and white matter brain regions of patients diagnosed with multiple sclerosis (MS) to those diagnosed with secondary demyelinating diseases such as neurosarcoid and acute disseminated encephalomyelitis (ADEM). Materials and Methods: Diffusion weighted scans were performed and apparent diffusion coefficients of 12 regions of interest were determined in 30 MS patients, 21 neurosarcoid patients, and 4 ADEM patients. Results: Mean apparent diffusion coefficients were significantly higher in MS patients than in non-MS patients in 6 of 6 of the corpus callosal regions assessed but not in any of the non-callosal white or gray matter regions assessed. Conclusion: Elevated apparent diffusion coefficients within the corpus callosum on diffusion weighted imaging may potentially help differentiate between patients with MS and patients with other diseases affecting the central nervous system white matter.

Original languageEnglish
Pages (from-to)732-736
Number of pages5
JournalJournal of Magnetic Resonance Imaging
Volume30
Issue number4
DOIs
StatePublished - Oct 2009

Keywords

  • ADEM
  • Apparent diffusion coefficient
  • Corpus callosum
  • Diffusion weighted imaging
  • Multiple Sclerosis
  • Neurosarcoid

Fingerprint

Dive into the research topics of 'Differentiating multiple sclerosis from other causes of demyelination using diffusion weighted imaging of the corpus callosum'. Together they form a unique fingerprint.

Cite this