TY - JOUR
T1 - Differential Susceptibility to Adolescent Externalizing Trajectories
T2 - Examining the Interplay Between CHRM2 and Peer Group Antisocial Behavior
AU - Latendresse, Shawn J.
AU - Bates, John E.
AU - Goodnight, Jackson A.
AU - Lansford, Jennifer E.
AU - Budde, John P.
AU - Goate, Alison
AU - Dodge, Kenneth A.
AU - Pettit, Gregory S.
AU - Dick, Danielle M.
PY - 2011/11
Y1 - 2011/11
N2 - The present study characterized prototypical patterns of development in self-reported externalizing behavior, between 12 and 22years of age, within a community sample of 452 genotyped individuals. A Caucasian subset (n=378) was then examined to determine whether their probabilities of displaying discrete trajectories were differentially associated with CHRM2, a gene implicated in self-regulatory processes across a range of externalizing behaviors, and if affiliating with antisocial peers moderated these associations. Findings indicate that relative to a normative "lower risk" externalizing trajectory, likelihood of membership in two "higher risk" trajectories increased with each additional copy of the minor allelic variant at CHRM2, and that this association was exacerbated among those exposed to higher levels of peer group antisocial behavior.
AB - The present study characterized prototypical patterns of development in self-reported externalizing behavior, between 12 and 22years of age, within a community sample of 452 genotyped individuals. A Caucasian subset (n=378) was then examined to determine whether their probabilities of displaying discrete trajectories were differentially associated with CHRM2, a gene implicated in self-regulatory processes across a range of externalizing behaviors, and if affiliating with antisocial peers moderated these associations. Findings indicate that relative to a normative "lower risk" externalizing trajectory, likelihood of membership in two "higher risk" trajectories increased with each additional copy of the minor allelic variant at CHRM2, and that this association was exacerbated among those exposed to higher levels of peer group antisocial behavior.
UR - http://www.scopus.com/inward/record.url?scp=81355134000&partnerID=8YFLogxK
U2 - 10.1111/j.1467-8624.2011.01640.x
DO - 10.1111/j.1467-8624.2011.01640.x
M3 - Article
C2 - 21883161
AN - SCOPUS:81355134000
SN - 0009-3920
VL - 82
SP - 1797
EP - 1814
JO - Child Development
JF - Child Development
IS - 6
ER -