Differential metabolic rates in prefrontal and temporal Brodmann areas in schizophrenia and schizotypal personality disorder

Monte S. Buchsbaum, Igor Nenadic, Erin A. Hazlett, Jacqueline Spiegel-Cohen, Michael B. Fleischman, Arash Akhavan, Jeremy M. Silverman, Larry J. Siever

Research output: Contribution to journalArticlepeer-review

92 Scopus citations

Abstract

In an exploration of the schizophrenia spectrum, we compared cortical metabolic rates in unmedicated patients with schizophrenia and schizotypal personality disorder (SPD) with findings in age- and sex-matched normal volunteers. Coregistered magnetic resonance imaging (MRI) and positron emission tomography (PET) scans were obtained in 27 schizophrenic, 13 SPD, and 32 normal volunteers who performed a serial verbal learning test during tracer uptake. A template of Brodmann areas derived from a whole brain histological section atlas was used to analyze PET findings. Significantly lower metabolic rates were found in prefrontal areas 44-46 in schizophrenic patients than in normal volunteers. SPD patients did not differ from normal volunteers in most lateral frontal regions, but they had values intermediate between those of normal volunteers and schizophrenic patients in lateral temporal regions. SPD patients showed higher than normal metabolic rates in both medial frontal and medial temporal areas. Metabolic rates in Brodmann area 10 were distinctly higher in SPD patients than in either normal volunteers or schizophrenic patients.

Original languageEnglish
Pages (from-to)141-150
Number of pages10
JournalSchizophrenia Research
Volume54
Issue number1-2
DOIs
StatePublished - 1 Mar 2002

Keywords

  • Frontal lobe
  • Magnetic resonance imaging (MRI)
  • Positron emission tomography (PET)
  • Temporal lobe

Fingerprint

Dive into the research topics of 'Differential metabolic rates in prefrontal and temporal Brodmann areas in schizophrenia and schizotypal personality disorder'. Together they form a unique fingerprint.

Cite this