Differential inhibition of type I interferon induction by arenavirus nucleoproteins

Luis Martínez-Sobrido, Panagiotis Giannakas, Beatrice Cubitt, Adolfo García-Sastre, Juan Carlos De La Torre

Research output: Contribution to journalArticlepeer-review

153 Scopus citations

Abstract

We have documented that the nucleoprotein (NP) of the prototypic arenavirus lymphocytic choriomeningitis virus is an antagonist of the type I interferon response. In this study we tested the ability of NPs encoded by representative arenavirus species from both Old World and New World antigenic groups to inhibit production of interferon. We found that, with the exception of Tacaribe virus (TCRV), all NPs tested inhibited activation of beta interferon and interferon regulatory factor 3 (IRF-3)-dependent promoters, as well as the nuclear translocation of IRF-3. Consistent with this observation, TCRV-infected cells also failed to inhibit interferon production.

Original languageEnglish
Pages (from-to)12696-12703
Number of pages8
JournalJournal of Virology
Volume81
Issue number22
DOIs
StatePublished - Nov 2007

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