TY - JOUR
T1 - Differential inhibition of type I interferon induction by arenavirus nucleoproteins
AU - Martínez-Sobrido, Luis
AU - Giannakas, Panagiotis
AU - Cubitt, Beatrice
AU - García-Sastre, Adolfo
AU - De La Torre, Juan Carlos
PY - 2007/11
Y1 - 2007/11
N2 - We have documented that the nucleoprotein (NP) of the prototypic arenavirus lymphocytic choriomeningitis virus is an antagonist of the type I interferon response. In this study we tested the ability of NPs encoded by representative arenavirus species from both Old World and New World antigenic groups to inhibit production of interferon. We found that, with the exception of Tacaribe virus (TCRV), all NPs tested inhibited activation of beta interferon and interferon regulatory factor 3 (IRF-3)-dependent promoters, as well as the nuclear translocation of IRF-3. Consistent with this observation, TCRV-infected cells also failed to inhibit interferon production.
AB - We have documented that the nucleoprotein (NP) of the prototypic arenavirus lymphocytic choriomeningitis virus is an antagonist of the type I interferon response. In this study we tested the ability of NPs encoded by representative arenavirus species from both Old World and New World antigenic groups to inhibit production of interferon. We found that, with the exception of Tacaribe virus (TCRV), all NPs tested inhibited activation of beta interferon and interferon regulatory factor 3 (IRF-3)-dependent promoters, as well as the nuclear translocation of IRF-3. Consistent with this observation, TCRV-infected cells also failed to inhibit interferon production.
UR - http://www.scopus.com/inward/record.url?scp=36048934428&partnerID=8YFLogxK
U2 - 10.1128/JVI.00882-07
DO - 10.1128/JVI.00882-07
M3 - Article
C2 - 17804508
AN - SCOPUS:36048934428
SN - 0022-538X
VL - 81
SP - 12696
EP - 12703
JO - Journal of Virology
JF - Journal of Virology
IS - 22
ER -