Differential dose-dependent effects of central morphine treatment upon food intake in male and female rats receiving neonatal hormone manipulations

Richard J. Bodnar, Maria M. Hadjimarkou, Eliza K. Krzanowska, Robert M. Silva, June A. Stein

Research output: Contribution to journalArticlepeer-review

12 Scopus citations

Abstract

Male rats display significantly greater analgesic responses following morphine than female rats, with neonatal gonadal manipulations reversing the sex-dependent pattern. The present study assessed whether dose-dependent (0.0005-5 μg, icv) effects of morphine-induced feeding were sensitive to sex-dependent and neonatal gonadectomy manipulations. Sex differences in morphine-induced feeding varied as a function of morphine dose with males showing greater increases at low (0.0005 μg) doses, and females showing greater increases at high (5 μg) doses. Neonatal castration, respectively, enhanced and reduced morphine-induced feeding at very low (0.0005 μg) and low (0.005 μg) doses. In contrast, neonatal testosterone administered to females enhanced morphine-induced feeding at higher (0.5-5 μg) doses. These data indicate that sex and neonatal gonadectomy differences in morphine-induced feeding are dependent upon the dose of morphine employed.

Original languageEnglish
Pages (from-to)53-57
Number of pages5
JournalNutritional Neuroscience
Volume6
Issue number1
DOIs
StatePublished - Feb 2003
Externally publishedYes

Keywords

  • Feeding
  • Morphine
  • Neonatal gonadectomy
  • Sex differences

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