TY - JOUR
T1 - Differential distribution and regulation of estrogen receptor-α and -β mRNA within the female rat brain
AU - Österlund, Marie
AU - G.j.m. Kuiper, George
AU - Gustafsson, Jan Åke
AU - Hurd, Yasmin L.
N1 - Funding Information:
We thank Ms. Haleh Razani and Prof. Sven-Ove Ögren for generously sharing technical services with handling the animals and Ms. Siv Eriksson for technical assistance. This work was supported by grants from the Stiftelsen Söderström Königska Sjukhemmet, Fredrik och Ingrid Thurings Stiftelse, and Kapten Arthur Erikssons Stiftelse.
PY - 1998/2
Y1 - 1998/2
N2 - In the present study, estrogen receptor (ER)α and ERβ genes were found to be differentially expressed in discrete subregions of the rat amygdaloid complex. The amygdala nuclei showing predominant ERα mRNA expression included the posterolateral cortical nucleus, amygdala hippocampal area, and lateral dorsolateral nucleus, whereas the amygdala areas with predominant ERβ mRNA expression were the medial anterodorsal and central nuclei. Both ERα and ERβ mRNAs were highly expressed in the medial posterodorsal nucleus. In addition to the discrete anatomical expression patterns, there appeared to be a differential regulation by estradiol of the ERα and ERβ mRNAs. Two weeks of estradiol (170 μg total) treatment decreased ERα mRNA expression levels in the arcuate, ventromedial hypothalamus, and posterolateral cortical amygdala nucleus, but increased ERβ mRNA in the arcuate. In the medial amygdala nuclei, only ERβ mRNA levels were altered (reduced) by estradiol treatment. These results suggest that estrogen can modulate behaviors and functions mediated by the amygdala and hypothalamus via differentially regulated ER subtypes.
AB - In the present study, estrogen receptor (ER)α and ERβ genes were found to be differentially expressed in discrete subregions of the rat amygdaloid complex. The amygdala nuclei showing predominant ERα mRNA expression included the posterolateral cortical nucleus, amygdala hippocampal area, and lateral dorsolateral nucleus, whereas the amygdala areas with predominant ERβ mRNA expression were the medial anterodorsal and central nuclei. Both ERα and ERβ mRNAs were highly expressed in the medial posterodorsal nucleus. In addition to the discrete anatomical expression patterns, there appeared to be a differential regulation by estradiol of the ERα and ERβ mRNAs. Two weeks of estradiol (170 μg total) treatment decreased ERα mRNA expression levels in the arcuate, ventromedial hypothalamus, and posterolateral cortical amygdala nucleus, but increased ERβ mRNA in the arcuate. In the medial amygdala nuclei, only ERβ mRNA levels were altered (reduced) by estradiol treatment. These results suggest that estrogen can modulate behaviors and functions mediated by the amygdala and hypothalamus via differentially regulated ER subtypes.
KW - 17β-estradiol
KW - Amygdala
KW - Hypothalamus
KW - In situ hybridization
KW - Steroid hormone
UR - http://www.scopus.com/inward/record.url?scp=0031910162&partnerID=8YFLogxK
U2 - 10.1016/S0169-328X(97)00351-3
DO - 10.1016/S0169-328X(97)00351-3
M3 - Article
C2 - 9526077
AN - SCOPUS:0031910162
SN - 0169-328X
VL - 54
SP - 175
EP - 180
JO - Molecular Brain Research
JF - Molecular Brain Research
IS - 1
ER -