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Different Fumaric Acid Esters Elicit Distinct Pharmacologic Responses
Brian T. Wipke
, Robert Hoepner
, Katrin Strassburger-Krogias
, Ankur M. Thomas
, Davide Gianni
, Suzanne Szak
, Melanie S. Brennan
, Maximilian Pistor
, Ralf Gold
, Andrew Chan
, Robert H. Scannevin
Research output
:
Contribution to journal
›
Article
›
peer-review
12
Scopus citations
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Keyphrases
Fumaric Acid Esters
100%
Dimethyl Fumarate
100%
Pharmacologic Response
100%
Fumarate
88%
Rodents
16%
Monotherapy
16%
Absolute Lymphocyte Count
16%
Cynomolgus Monkey
11%
Apoptotic Pathway
11%
Pharmacodynamic Interactions
11%
Kidney
5%
Lymphocytes
5%
Regression Analysis
5%
Lymphopenia
5%
CD8+ T Cells
5%
Biological Response
5%
Differentially Expressed Genes
5%
Retrospective Cohort
5%
Transcriptional Profiling
5%
Immunosuppressive Medication
5%
Pharmacokinetic Effects
5%
Stress Response Pathway
5%
Nuclear Factor Erythroid 2-related Factor 2 (Nrf2)
5%
Oxidative Stress Response
5%
MS n
5%
Primary Metabolites
5%
Gene Profile
5%
Lymphocyte Count
5%
Biodistribution
5%
Psoriasis Therapy
5%
Immune Tissue
5%
Specific Response
5%
Biological Changes
5%
Observational Analysis
5%
Strong Potential
5%
Brain Penetration
5%
Fumaderm
5%
Pharmacodynamic Response
5%
Acid Esters
5%
Monomethyl Fumarate
5%
Tecfidera
5%
Pharmacology, Toxicology and Pharmaceutical Science
Fumaric Acid
100%
Fumaric Acid Dimethyl Ester
100%
Fumaric Acid Ethyl Ester
84%
Monotherapy
15%
Pharmacodynamics
15%
Transcription Factor Nrf2
10%
Macaca fascicularis
10%
Immunosuppressive Agent
5%
Lymphocytopenia
5%
Psoriasis
5%
CD8 Antigen
5%
Biodistribution
5%
Fumaderm
5%
Fumaric Acid Methyl Ester
5%
Pharmacokinetics
5%
Neuroscience
Lymphocyte
100%
Transcription Factor Nrf2
40%
Programmed Cell Death
40%
Oxidative Stress
20%
T Cell
20%
Lymphocytopenia
20%
CD8
20%
Immunosuppressive Drug
20%
Pharmacokinetics
20%
Immunology and Microbiology
Fumaric Acid Dimethyl Ester
100%
Lymphocyte Count
21%
Pharmacodynamics
15%
Transcription Factor Nrf2
10%
Macaca fascicularis
10%
Programmed Cell Death
10%
Metabolite
5%
Cytotoxic T-Cell
5%
Immunosuppressive Drug
5%
Oxidative Stress
5%
Pharmacokinetics
5%
Lymphocytopenia
5%
Lymphocyte
5%
Gene Expression Assay
5%