Differences in regional brain metabolic responses between single and repeated doses of methylphenidate

Nora D. Volkow, Gene Jack Wang, Joanna S. Fowler, Robert Hitzemann, John Gatley, Yu Shin Ding, Christopher Wong, Naome Pappas

Research output: Contribution to journalArticlepeer-review

34 Scopus citations


Studies investigating the acute effects of drugs of abuse on human brain metabolism have measured single doses whereas these drugs are mostly taken repeatedly. Here we compared the brain metabolic response to intravenous methylphenidate when given after a single dose to that when given after two sequential doses. Methylphenidate-induced changes in metabolism differed; whereas single doses tended to decrease metabolism, repeated doses tended to increase it, and these differences were significant in frontal, parietal and occipital cortices and hippocampus. This indicates that methylphenidate's metabolic effects vary with acute previous exposure and highlights the importance of studying drugs after single and repeated administration.

Original languageEnglish
Pages (from-to)29-36
Number of pages8
JournalPsychiatry Research - Neuroimaging
Issue number1
StatePublished - 15 Jul 1998
Externally publishedYes


  • Bingeing
  • Cocaine
  • Craving
  • Dopamine
  • Drug addiction
  • FDG
  • PET


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