TY - JOUR
T1 - Differences in Maternal and Paternal Transmission of Coronary Heart Disease
AU - Sundquist, Kristina
AU - Li, Xinjun
N1 - Funding Information:
This work was supported by the National Institutes of Health (grant R01-H271084-1), Knut and Alice Wallenberg Foundation, Stockholm County Council, Karolinska Institute, Swedish Research Council (grant K2001-27X-11651-06C), and the Swedish Council for Working Life and Social Research (grant 2001-2373). All authors had full access to all of the data in the study, and take responsibility for the integrity of the data and the accuracy of the data analysis.
PY - 2006/6
Y1 - 2006/6
N2 - Background: Few studies have investigated the possible differential transmission of maternal and/or paternal coronary heart disease (CHD) to offspring, after accounting for sociodemographic characteristics. Methods: The Multigeneration Register was linked to hospital data in this study of all Swedish individuals born since 1932 and their parents. Registered cases of CHD between January 1, 1987, and December 31, 2001, were evaluated. Poisson regression was used to calculate standardized incidence ratios (SIRs) for men and women with mothers and/or fathers affected by CHD compared with men and women whose parents were not affected. All analyses were conducted in 2005. Results: Maternal transmission was stronger than paternal transmission and the confidence intervals did not overlap. For women, the overall SIRs were 1.43 (95% confidence interval [CI]=1.34-1.51) for maternal transmission and 1.17 (95% CI=1.11-1.23) for paternal transmission. For men, the corresponding SIRs were 1.55 (95% CI=1.50-1.60) and 1.41 (95% CI=1.37-1.45). Even higher SIRs were found in the youngest age groups, among those with both parents affected by coronary heart disease, and among those with premature parental CHD. Conclusions: These findings might ultimately influence treatment decisions regarding risk factors and suggest the need for research focusing on genetic and intrauterine risk factors.
AB - Background: Few studies have investigated the possible differential transmission of maternal and/or paternal coronary heart disease (CHD) to offspring, after accounting for sociodemographic characteristics. Methods: The Multigeneration Register was linked to hospital data in this study of all Swedish individuals born since 1932 and their parents. Registered cases of CHD between January 1, 1987, and December 31, 2001, were evaluated. Poisson regression was used to calculate standardized incidence ratios (SIRs) for men and women with mothers and/or fathers affected by CHD compared with men and women whose parents were not affected. All analyses were conducted in 2005. Results: Maternal transmission was stronger than paternal transmission and the confidence intervals did not overlap. For women, the overall SIRs were 1.43 (95% confidence interval [CI]=1.34-1.51) for maternal transmission and 1.17 (95% CI=1.11-1.23) for paternal transmission. For men, the corresponding SIRs were 1.55 (95% CI=1.50-1.60) and 1.41 (95% CI=1.37-1.45). Even higher SIRs were found in the youngest age groups, among those with both parents affected by coronary heart disease, and among those with premature parental CHD. Conclusions: These findings might ultimately influence treatment decisions regarding risk factors and suggest the need for research focusing on genetic and intrauterine risk factors.
UR - https://www.scopus.com/pages/publications/33646408794
U2 - 10.1016/j.amepre.2006.01.010
DO - 10.1016/j.amepre.2006.01.010
M3 - Article
C2 - 16704941
AN - SCOPUS:33646408794
SN - 0749-3797
VL - 30
SP - 480
EP - 486
JO - American Journal of Preventive Medicine
JF - American Journal of Preventive Medicine
IS - 6
ER -