@article{7650a57a805d439f953828c7f49b321f,
title = "Differences in cognitive impairment in primary age-related tauopathy versus Alzheimer disease",
abstract = "This study examined differences in neuropsychological test scores between individuals with primary age-related tauopathy (PART) and Alzheimer disease (AD) using cross-sectional data from the National Alzheimer's Coordinating Center. Linear regression tested for differences in 4 cognitive domains stratified by cognitive status (global Clinical Dementia Rating [CDR]). The sample included 240 participants with no neuritic plaques (NP) (definite PART), 186 with sparse NP (possible PART), and 510 with moderate/frequent NP (AD). Four cognitive domain z-score outcome variables (memory, attention, executive function, and semantic memory/language) were calculated using 12 neuropsychological tests. Definite PART participants had a sparing of semantic memory/language compared to those with AD, with a mean adjusted z-score difference of 0.37 (95% confidence interval [CI]: 0.16-0.58) for those with CDR ¼ 0.5 or 1 and of 0.92 (CI: 0.22-1.63) for those with CDR ¼ 2 or 3. Compared to participants with AD, definite PART participants with CDR ¼ 0.5 or 1 had sparing of memory (adjusted z-score difference: 0.61; CI: 0.39-0.84) and definite PART participants with CDR ¼ 2 or 3 had sparing of attention (adjusted z-score difference: 0.76: CI: 0.09-1.43). Patterns of cognitive impairment differed between definite PART and AD, suggesting significant differences in clinical presentation between individuals from these 2 groups.",
keywords = "AD, Alzheimer disease, Cognition, Cognitive, Neuropathology, PART, Primary age-related tauopathy",
author = "Besser, {Lilah M.} and Charles Mock and Teylan, {Merilee A.} and Jason Hassenstab and Kukull, {Walter A.} and Crary, {John F.}",
note = "Funding Information: From the School of Urban and Regional Planning, Institute for Healthy Ag-ing and Lifespan Studies, Florida Atlantic University, Boca Raton, Flor-ida (LMB); Department of Epidemiology, National Alzheimer{\textquoteright}s Coordinating Center, University of Washington, Seattle, Washington (CM, MAT, WAK); Department of Neurology, Washington University in St. Louis, St. Louis, Missouri (JH); Department of Psychological & Brain Sciences, Washington University in St. Louis, St. Louis, Missouri (JH); and Department of Pathology, Fishberg Department of Neurosci-ence, Friedman Brain Institute, Ronald M. Loeb Center for Alzheimer{\textquoteright}s Disease, Icahn School of Medicine at Mount Sinai, New York, New York (JFC) Send correspondence to: Lilah M. Besser, PhD, Florida Atlantic University, 777 Glades Rd, SO 44, Room 371, Boca Raton, FL 33431; E-mail: lbesser@fau.edu The NACC database is funded by NIA/NIH Grant U01 AG016976. Dr John Crary is supported by National Institutes of Health Grants R01 NS095252 (PI), R01 AG054008 (PI), RF1 AG06096 (PI), R01 AG062348 (PI), Alzheimer{\textquoteright}s Association NIRG-15-363188 (PI), and the Tau Consortium (PI). NACC data are contributed by the NIA-funded ADCs: P30 AG019610 (PI Eric Reiman, MD), P30 AG013846 (PI Neil Kowall, MD), P50 AG008702 (PI Scott Small, MD), P50 AG025688 (PI Allan Levey, MD, PhD), P50 AG047266 (PI Todd Golde, MD, PhD), P30 AG010133 (PI Andrew Saykin, PsyD), P50 AG005146 (PI Marilyn Albert, PhD), P50 AG005134 (PI Bradley Hyman, MD, PhD), P50 AG016574 (PI Ronald Petersen, MD, PhD), P50 AG005138 (PI Mary Sano, PhD), P30 AG008051 (PI Steven Ferris, PhD), P30 AG013854 (PI M. Marsel Mesulam, MD), P30 AG008017 (PI Jeffrey Kaye, MD), P30 AG010161 (PI David Bennett, MD), P50 AG047366 (PI Victor Hender-son, MD, MS), P30 AG010129 (PI Charles DeCarli, MD), P50 AG016573 (PI Frank LaFerla, PhD), P50 AG016570 (PI Marie-Francoise Chesselet, MD, PhD), P50 AG005131 (PI Douglas Galasko, MD), P50 AG023501 (PI Bruce Miller, MD), P30 AG035982 (PI Russell Swerdlow, MD), P30 AG028383 (PI Linda Van Eldik, PhD), P30 AG010124 (PI John Trojanowski, MD, PhD), P50 AG005133 (PI Oscar Lopez, MD), P50 AG005142 (PI Helena Chui, MD), P30 AG012300 (PI Roger Rosenberg, MD), P50 AG005136 (PI Thomas Montine, MD, PhD), P50 AG033514 (PI Sanjay Asthana, MD, FRCP), P50 AG005681 (PI John Morris, MD), and P50 AG047270 (PI Stephen Strittmatter, MD, PhD). Publisher Copyright: {\textcopyright} 2019 American Association of Neuropathologists, Inc. All rights reserved.",
year = "2019",
month = mar,
day = "1",
doi = "10.1093/jnen/nly132",
language = "English",
volume = "78",
pages = "219--228",
journal = "Journal of Neuropathology and Experimental Neurology",
issn = "0022-3069",
publisher = "Oxford University Press",
number = "3",
}