TY - JOUR
T1 - Dietary protein antigenemia in humoral immunodeficiency. Correlation with splenomegaly
AU - Cunningham-Rundles, Charlotte
AU - Carr, Ronald I.
AU - Good, Robert A.
N1 - Funding Information:
From the Memorial Sloan-Kettering Cancer Center, New York, New York, the National Jewish Hosoital. Denver, Colorado, and the Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma. This work was supported by United States Public Health Service Grants Al-18589, CA-19267, and CA-29502, American Cancer Society Grant ACS-M-245, and a grant from the Zelda R. Weintraub Cancer Fund. Requests for reprints should be addressed to Dr. Charlotte CunninghamRundles, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, New York 10021. Manuscript accepted July 7, 1983.
PY - 1984/2
Y1 - 1984/2
N2 - Enhanced gastrointestinal absorption of dietary substances is an important feature of normal neonatal life that also exists in particular disease states such as selective IgA deficiency and atopic allergy. In these studies, it is shown that patients with hypogammaglobulinemia have increased absorption of dietary bovine antigens and that most patients have large amounts of these proteins present in the serum even after an overnight fast. The amounts of such proteins were found to be correlated with spleen size and/or peripheral lymphoid hypertrophy. Interestingly, three patients with X-linked agammaglobulinemia did not have detectable amounts of these proteins in the serum nor did they have splenomegaly or lymphadenopathy. It is speculated that hypogammaglobulinemic patients have a specific gastrointestinal mucosal lesion that permits the chronic excessive absorption of dietary antigens and may result in lymphoid hypertrophy.
AB - Enhanced gastrointestinal absorption of dietary substances is an important feature of normal neonatal life that also exists in particular disease states such as selective IgA deficiency and atopic allergy. In these studies, it is shown that patients with hypogammaglobulinemia have increased absorption of dietary bovine antigens and that most patients have large amounts of these proteins present in the serum even after an overnight fast. The amounts of such proteins were found to be correlated with spleen size and/or peripheral lymphoid hypertrophy. Interestingly, three patients with X-linked agammaglobulinemia did not have detectable amounts of these proteins in the serum nor did they have splenomegaly or lymphadenopathy. It is speculated that hypogammaglobulinemic patients have a specific gastrointestinal mucosal lesion that permits the chronic excessive absorption of dietary antigens and may result in lymphoid hypertrophy.
UR - http://www.scopus.com/inward/record.url?scp=0021321812&partnerID=8YFLogxK
U2 - 10.1016/0002-9343(84)90771-X
DO - 10.1016/0002-9343(84)90771-X
M3 - Article
C2 - 6198909
AN - SCOPUS:0021321812
SN - 0002-9343
VL - 76
SP - 181
EP - 185
JO - American Journal of Medicine
JF - American Journal of Medicine
IS - 2
ER -