TY - JOUR
T1 - Dietary and reproductive determinants of plasma organochlorine levels in pregnant women in Rio de Janeiro
AU - Sarcinelli, Paula N.
AU - Pereira, Ana Cristina S.
AU - Mesquita, Sueli A.
AU - Oliveira-Silva, Jefferson J.
AU - Meyer, Armando
AU - Menezes, Marco A.C.
AU - Alves, Sérgio R.
AU - Mattos, Rita C.O.C.
AU - Moreira, Josino C.
AU - Wolff, Mary
N1 - Funding Information:
Drs. Paula Sarcinelli and Rita Mattos are Selikoff Fellows and Dr. Mary Wolff is faculty associated with the Mount Sinai/Queens College International Training Program in Environmental and Occupational Health. This research was supported in part by Grant 1 D43 TW00640 from the Fogarty International Center of the National Institutes of Health.
PY - 2003/3
Y1 - 2003/3
N2 - Organochlorine (OC) plasma levels and their dietary and reproductive determinants were investigated in 64 pregnant women from Rio de Janeiro, Brazil. Prenatal exposure of newborns was evaluated in a subset of these women in which umbilical cord blood was analyzed. To assess the influence of dietary factors on OC levels, a semiquantitative food frequency questionnaire was completed by participants. Nondietary determinants were investigated through a general questionnaire that addressed reproductive history, lifestyle, and social-demographic characteristics. Both women and their newborns had detectable but low levels of OCs. The most frequently detected compound was p,p′-DDE, the main metabolite of p,p′-DDT. This compound was found in 97% of the women who participated in the study and in 67% of the umbilical cord blood samples, with levels ranging from 0.161 to 8.03ppb and from 0.320 to 1.06ppb, respectively. Among the OCs detected, only p,p′-DDE showed any correlation with dietary and nondietary factors. There was a positive correlation between maternal p,p′-DDE and the consumption of fish (Pearson r=0.38,P=0.002) and chicken (Pearson r=0.26, P=0.042). The correlation between pork consumption and p,p′-DDE exhibited an inverse relationship (Pearson r=-0.25,P=0.052). Parity was the only nondietary factor that showed a significant correlation (Pearson r=-0.36,P=0.004). The main determinants of p,p′-DDE levels in this group of women were fish consumption and parity, together explaining 28% of the variance (P<001), in a multivariate model.
AB - Organochlorine (OC) plasma levels and their dietary and reproductive determinants were investigated in 64 pregnant women from Rio de Janeiro, Brazil. Prenatal exposure of newborns was evaluated in a subset of these women in which umbilical cord blood was analyzed. To assess the influence of dietary factors on OC levels, a semiquantitative food frequency questionnaire was completed by participants. Nondietary determinants were investigated through a general questionnaire that addressed reproductive history, lifestyle, and social-demographic characteristics. Both women and their newborns had detectable but low levels of OCs. The most frequently detected compound was p,p′-DDE, the main metabolite of p,p′-DDT. This compound was found in 97% of the women who participated in the study and in 67% of the umbilical cord blood samples, with levels ranging from 0.161 to 8.03ppb and from 0.320 to 1.06ppb, respectively. Among the OCs detected, only p,p′-DDE showed any correlation with dietary and nondietary factors. There was a positive correlation between maternal p,p′-DDE and the consumption of fish (Pearson r=0.38,P=0.002) and chicken (Pearson r=0.26, P=0.042). The correlation between pork consumption and p,p′-DDE exhibited an inverse relationship (Pearson r=-0.25,P=0.052). Parity was the only nondietary factor that showed a significant correlation (Pearson r=-0.36,P=0.004). The main determinants of p,p′-DDE levels in this group of women were fish consumption and parity, together explaining 28% of the variance (P<001), in a multivariate model.
KW - Dietary and reproductive determinants
KW - Organochlorines
KW - Plasma
KW - p,p′-DDE
UR - https://www.scopus.com/pages/publications/0037336319
U2 - 10.1016/S0013-9351(02)00053-1
DO - 10.1016/S0013-9351(02)00053-1
M3 - Article
C2 - 12648476
AN - SCOPUS:0037336319
SN - 0013-9351
VL - 91
SP - 143
EP - 150
JO - Environmental Research
JF - Environmental Research
IS - 3
ER -