Dichotomous effect of aerosolized hyaluronan in a hamster model of endotoxin-induced lung injury

Priya P. Nadkarni; Girish S. Kulkarni; Joseph M. Cerreta; Shuren Ma; Jerome O. Cantor

doi:10.1080/01902140600574942

Dichotomous effect of aerosolized hyaluronan in a hamster model of endotoxin-induced lung injury

Priya P. Nadkarni, Girish S. Kulkarni, Joseph M. Cerreta, Shuren Ma, Jerome O. Cantor

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

Inhalation of aerosolized low-molecular-weight (150-kDa) hyaluronan (HA) was previously shown by this laboratory to prevent experimentally induced pulmonary emphysema without associated toxicity. Nevertheless, other investigators have found that low-molecular-weight HA may be proinflammatory, prompting the authors to determine if aerosolized HA could possibly enhance pulmonary inflammation in a different model of lung injury involving intratracheal instillation of endotoxin to hamsters. Results indicate that exposure to HA following endotoxin administration significantly increased lung inflammation, whereas pretreatment with HA had the opposite effect.

Original language	English
Pages (from-to)	807-818
Number of pages	12
Journal	Experimental Lung Research
Volume	31
Issue number	9-10
DOIs	https://doi.org/10.1080/01902140600574942
State	Published - Nov 2005

Keywords

Anti-inflammatory
Endotoxin
Hyaluronan
Inflammation
Lung

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10.1080/01902140600574942

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title = "Dichotomous effect of aerosolized hyaluronan in a hamster model of endotoxin-induced lung injury",

abstract = "Inhalation of aerosolized low-molecular-weight (150-kDa) hyaluronan (HA) was previously shown by this laboratory to prevent experimentally induced pulmonary emphysema without associated toxicity. Nevertheless, other investigators have found that low-molecular-weight HA may be proinflammatory, prompting the authors to determine if aerosolized HA could possibly enhance pulmonary inflammation in a different model of lung injury involving intratracheal instillation of endotoxin to hamsters. Results indicate that exposure to HA following endotoxin administration significantly increased lung inflammation, whereas pretreatment with HA had the opposite effect.",

keywords = "Anti-inflammatory, Endotoxin, Hyaluronan, Inflammation, Lung",

author = "Nadkarni, {Priya P.} and Kulkarni, {Girish S.} and Cerreta, {Joseph M.} and Shuren Ma and Cantor, {Jerome O.}",

note = "Funding Information: Received 15 September 2005; accepted 12 January 2006. This work was supported by a grant from the Alpha-1 Foundation and internal funds from the Department of Pharmacy and Allied Health Sciences at St John{\textquoteright}s University. Address correspondence to Jerome O. Cantor, MD, St John{\textquoteright}s University (SAH 128), Jamaica, NY 11439, USA. E-mail: [email protected]",

year = "2005",

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doi = "10.1080/01902140600574942",

language = "English",

volume = "31",

pages = "807--818",

journal = "Experimental Lung Research",

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AU - Nadkarni, Priya P.

AU - Kulkarni, Girish S.

AU - Cerreta, Joseph M.

AU - Ma, Shuren

AU - Cantor, Jerome O.

N1 - Funding Information: Received 15 September 2005; accepted 12 January 2006. This work was supported by a grant from the Alpha-1 Foundation and internal funds from the Department of Pharmacy and Allied Health Sciences at St John’s University. Address correspondence to Jerome O. Cantor, MD, St John’s University (SAH 128), Jamaica, NY 11439, USA. E-mail: [email protected]

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N2 - Inhalation of aerosolized low-molecular-weight (150-kDa) hyaluronan (HA) was previously shown by this laboratory to prevent experimentally induced pulmonary emphysema without associated toxicity. Nevertheless, other investigators have found that low-molecular-weight HA may be proinflammatory, prompting the authors to determine if aerosolized HA could possibly enhance pulmonary inflammation in a different model of lung injury involving intratracheal instillation of endotoxin to hamsters. Results indicate that exposure to HA following endotoxin administration significantly increased lung inflammation, whereas pretreatment with HA had the opposite effect.

AB - Inhalation of aerosolized low-molecular-weight (150-kDa) hyaluronan (HA) was previously shown by this laboratory to prevent experimentally induced pulmonary emphysema without associated toxicity. Nevertheless, other investigators have found that low-molecular-weight HA may be proinflammatory, prompting the authors to determine if aerosolized HA could possibly enhance pulmonary inflammation in a different model of lung injury involving intratracheal instillation of endotoxin to hamsters. Results indicate that exposure to HA following endotoxin administration significantly increased lung inflammation, whereas pretreatment with HA had the opposite effect.

KW - Anti-inflammatory

KW - Endotoxin

KW - Hyaluronan

KW - Inflammation

KW - Lung

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ER -

Dichotomous effect of aerosolized hyaluronan in a hamster model of endotoxin-induced lung injury

Abstract

Keywords

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