Diaminodichloroplatinum: A phase I study showing responses in testicular and other tumors

Donald J. Higby, Donald J. Higby, H. James Wallace, D. J. Albert, J. F. Holland

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239 Scopus citations

Abstract

Diaminodichloroplatinum was studied in a Phase I trial. Two dose schedules were explored. In Schedule I, a maximum dose of 100 mg/M2 given once was reached, and this proved too toxic for further use. The maximum dose in Schedule II, 24 mg/M2 daily for 5 days, was also too toxic, so 20 mg/M2 per day for 5 days was the dose selected for further exploration. Responses were seen in 1 patient with anaplastic thyroid carcinoma, 1 with transitional cell carcinoma of the bladder, and 1 with breast cancer. In patients with testicular tumors, responses were seen in 9 of 11 patients. There were 3 complete regressions seen, 1 in seminoma, 1 in embryonal cell carcinoma, and 1 in male choriocarcinoma. Three partial regressions, and three cases of objective improvement were also seen in this series. These were also distributed over different tumor types. The possibility that diaminodichloroplatinum has a specific effect on tissues arising from the genitourinary anlage is suggested.

Original languageEnglish
Pages (from-to)1219-1225
Number of pages7
JournalCancer
Volume33
Issue number5
DOIs
StatePublished - May 1974
Externally publishedYes

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