Diagnostic implications of p16 expression in serous papillary endometrial cancer

Itamar M. Netzer, Hedwiga Kerner, Ludmila Litwin, Lior Lowenstein, Amnon Amit

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11 Scopus citations


Objective: The purpose of this study was to examine whether the degree of expression of the p16 protein in serous papillary endometrial cancer bears a prognostic significance. The secondary objective was to establish the value of p16 immunohistochemical staining as an adjunct to diagnosis. Study Design: Archived paraffin blocks holding specimens from the uteri of 31 serous papillary and 31 endometrioid endometrial carcinoma patients were recut and restained for p16 and p53. Results: Overexpression of p16 was found in 78% of the serous papillary patients versus 36% of the endometrioid patients. p16 was not found to be an independent prognostic factor in serous papillary endometrial carcinoma. Conclusions: Although p16 was not found to have prognostic significance in serous papillary endometrial carcinoma, it may be valuable as a diagnostic adjunct in histologically ambiguous tumors.

Original languageEnglish
Pages (from-to)1441-1445
Number of pages5
JournalInternational Journal of Gynecological Cancer
Issue number8
StatePublished - Nov 2011
Externally publishedYes


  • Biomarkers
  • Endometrial carcinoma
  • Prognosis
  • Serous papillary


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