TY - JOUR
T1 - Diagnostic Criteria of Flow-Mediated Vasodilation for Normal Endothelial Function and Nitroglycerin-Induced Vasodilation for Normal Vascular Smooth Muscle Function of the Brachial Artery
AU - Maruhashi, Tatsuya
AU - Kajikawa, Masato
AU - Kishimoto, Shinji
AU - Hashimoto, Haruki
AU - Takaeko, Yuji
AU - Yamaji, Takayuki
AU - Harada, Takahiro
AU - Han, Yiming
AU - Aibara, Yoshiki
AU - Mohamad Yusoff, Farina
AU - Hidaka, Takayuki
AU - Kihara, Yasuki
AU - Chayama, Kazuaki
AU - Nakashima, Ayumu
AU - Goto, Chikara
AU - Tomiyama, Hirofumi
AU - Takase, Bonpei
AU - Kohro, Takahide
AU - Suzuki, Toru
AU - Ishizu, Tomoko
AU - Ueda, Shinichiro
AU - Yamazaki, Tsutomu
AU - Furumoto, Tomoo
AU - Kario, Kazuomi
AU - Inoue, Teruo
AU - Koba, Shinji
AU - Watanabe, Kentaro
AU - Takemoto, Yasuhiko
AU - Hano, Takuzo
AU - Sata, Masataka
AU - Ishibashi, Yutaka
AU - Node, Koichi
AU - Maemura, Koji
AU - Ohya, Yusuke
AU - Furukawa, Taiji
AU - Ito, Hiroshi
AU - Ikeda, Hisao
AU - Yamashina, Akira
AU - Higashi, Yukihito
N1 - Publisher Copyright:
© 2020 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley.
PY - 2020/1/21
Y1 - 2020/1/21
N2 - Background: Diagnostic criteria of flow-mediated vasodilation (FMD), an index of endothelial function, and nitroglycerin-induced vasodilation (NID), an index of vascular smooth muscle function, of the brachial artery have not been established. The purpose of this study was to propose diagnostic criteria of FMD and NID for normal endothelial function and normal vascular smooth muscle function. Methods and Results: We investigated the cutoff values of FMD and NID in subjects with (risk group) and those without cardiovascular risk factors or cardiovascular diseases (no-risk group) in 7277 Japanese subjects (mean age 51.4±10.8 years) from the Flow-Mediated Dilation Japan study and the Flow-Mediated Dilatation Japan Registry study for analysis of the cutoff value of FMD and in 1764 Japanese subjects (62.2±16.1 years) from the registry of Hiroshima University Hospital for analysis of the cutoff value of NID. Receiver-operator characteristic curve analysis of FMD to discriminate subjects in the no-risk group from patients in the risk group showed that the optimal cutoff value of FMD to diagnose subjects in the no-risk group was 7.1%. Receiver-operator characteristic curve analysis of NID to discriminate subjects in the no-risk group from patients in the risk group showed that the optimal cutoff value of NID to diagnose subjects in the no-risk group was 15.6%. Conclusions: We propose that the cutoff value for normal endothelial function assessed by FMD of the brachial artery is 7.1% and that the cutoff value for normal vascular smooth muscle function assessed by NID of the brachial artery is 15.6% in Japanese subjects. Clinical Trial Registration: www.umin.ac.jp Unique identifiers: UMIN000012950, UMIN000012951, UMIN000012952, and UMIN000003409.
AB - Background: Diagnostic criteria of flow-mediated vasodilation (FMD), an index of endothelial function, and nitroglycerin-induced vasodilation (NID), an index of vascular smooth muscle function, of the brachial artery have not been established. The purpose of this study was to propose diagnostic criteria of FMD and NID for normal endothelial function and normal vascular smooth muscle function. Methods and Results: We investigated the cutoff values of FMD and NID in subjects with (risk group) and those without cardiovascular risk factors or cardiovascular diseases (no-risk group) in 7277 Japanese subjects (mean age 51.4±10.8 years) from the Flow-Mediated Dilation Japan study and the Flow-Mediated Dilatation Japan Registry study for analysis of the cutoff value of FMD and in 1764 Japanese subjects (62.2±16.1 years) from the registry of Hiroshima University Hospital for analysis of the cutoff value of NID. Receiver-operator characteristic curve analysis of FMD to discriminate subjects in the no-risk group from patients in the risk group showed that the optimal cutoff value of FMD to diagnose subjects in the no-risk group was 7.1%. Receiver-operator characteristic curve analysis of NID to discriminate subjects in the no-risk group from patients in the risk group showed that the optimal cutoff value of NID to diagnose subjects in the no-risk group was 15.6%. Conclusions: We propose that the cutoff value for normal endothelial function assessed by FMD of the brachial artery is 7.1% and that the cutoff value for normal vascular smooth muscle function assessed by NID of the brachial artery is 15.6% in Japanese subjects. Clinical Trial Registration: www.umin.ac.jp Unique identifiers: UMIN000012950, UMIN000012951, UMIN000012952, and UMIN000003409.
KW - diagnostic criteria
KW - endothelial function
KW - flow-mediated vasodilation
KW - nitroglycerin-induced vasodilation
KW - vascular smooth muscle function
UR - https://www.scopus.com/pages/publications/85077720595
U2 - 10.1161/JAHA.119.013915
DO - 10.1161/JAHA.119.013915
M3 - Article
C2 - 31910779
AN - SCOPUS:85077720595
SN - 2047-9980
VL - 9
JO - Journal of the American Heart Association
JF - Journal of the American Heart Association
IS - 2
M1 - e013915
ER -