TY - JOUR
T1 - Diagnostic criteria for apathy in neurocognitive disorders
AU - Miller, David S.
AU - Robert, Philippe
AU - Ereshefsky, Larry
AU - Adler, Lawrence
AU - Bateman, Daniel
AU - Cummings, Jeff
AU - DeKosky, Steven T.
AU - Fischer, Corinne E.
AU - Husain, Masud
AU - Ismail, Zahinoor
AU - Jaeger, Judith
AU - Lerner, Alan J.
AU - Li, Abby
AU - Lyketsos, Constantine G.
AU - Manera, Valeria
AU - Mintzer, Jacobo
AU - Moebius, Hans J.
AU - Mortby, Moyra
AU - Meulien, Didier
AU - Pollentier, Stephane
AU - Porsteinsson, Anton
AU - Rasmussen, Jill
AU - Rosenberg, Paul B.
AU - Ruthirakuhan, Myuri T.
AU - Sano, Mary
AU - Zucchero Sarracini, Carla
AU - Lanctôt, Krista L.
N1 - Publisher Copyright:
© 2021 The Authors. Alzheimer's & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer's Association
PY - 2021/12
Y1 - 2021/12
N2 - Introduction: Apathy is common in neurocognitive disorders (NCD) but NCD-specific diagnostic criteria are needed. Methods: The International Society for CNS Clinical Trials Methodology Apathy Work Group convened an expert group and sought input from academia, health-care, industry, and regulatory bodies. A modified Delphi methodology was followed, and included an extensive literature review, two surveys, and two meetings at international conferences, culminating in a consensus meeting in 2019. Results: The final criteria reached consensus with more than 80% agreement on all parts and included: limited to people with NCD; symptoms persistent or frequently recurrent over at least 4 weeks, a change from the patient's usual behavior, and including one of the following: diminished initiative, diminished interest, or diminished emotional expression/responsiveness; causing significant functional impairment and not exclusively explained by other etiologies. Discussion: These criteria provide a framework for defining apathy as a unique clinical construct in NCD for diagnosis and further research.
AB - Introduction: Apathy is common in neurocognitive disorders (NCD) but NCD-specific diagnostic criteria are needed. Methods: The International Society for CNS Clinical Trials Methodology Apathy Work Group convened an expert group and sought input from academia, health-care, industry, and regulatory bodies. A modified Delphi methodology was followed, and included an extensive literature review, two surveys, and two meetings at international conferences, culminating in a consensus meeting in 2019. Results: The final criteria reached consensus with more than 80% agreement on all parts and included: limited to people with NCD; symptoms persistent or frequently recurrent over at least 4 weeks, a change from the patient's usual behavior, and including one of the following: diminished initiative, diminished interest, or diminished emotional expression/responsiveness; causing significant functional impairment and not exclusively explained by other etiologies. Discussion: These criteria provide a framework for defining apathy as a unique clinical construct in NCD for diagnosis and further research.
UR - https://www.scopus.com/pages/publications/85105082946
U2 - 10.1002/alz.12358
DO - 10.1002/alz.12358
M3 - Article
C2 - 33949763
AN - SCOPUS:85105082946
SN - 1552-5260
VL - 17
SP - 1892
EP - 1904
JO - Alzheimer's and Dementia
JF - Alzheimer's and Dementia
IS - 12
ER -